Nfatc4 (NM_023699) Mouse Untagged Clone

CAT#: MC204560

Nfatc4 (untagged) - Mouse nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 (Nfatc4), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Nfatc4
• Synonyms: 3110041H08Rik; AW107667; AW546455; Nfat3
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC028928
  GGCGGGACCTGGGGGCTCCGGCCGGATCCATGGGGGCCGCAAGCTGCGAGGATGAGGAGCTGGAATTTAA GCTGGTGTTCGGAGAGGAAAAGGAGCCCCCCCCGCTGGGCCCTGGGGGTCCTGGGGAAGAGCTGGACTCA GAGGATACCCCTCCATGCTGTCGTTTGGCCCTGGGGGAACCCCTTCCTTATGGTGCTGCCCCTATTGGGA TTCCCCGACCCCCACCCCCTCGGCCAGGGATGCACTCACCACCGCCCCGTCCCGCCCCTTCACCTGGCAC CTGGGAGAGCCAGCCAGCTAGGTCGGTGAGGCTGGGGGGCCCAGGAGGTAATGCAGGGGGTGCTGGGGGT GGTCGTGTTCTTGAGTGTCCCAGCATCCGGATTACCTCCATCTCTCCCACGCCTGACCCGCCGACCTCGC TAGAGGACACTCCTGAAACTTGGGGGGACGGCTCTCCTAGAGATTACCCTCCACCAGAAGGCTTTGGGGG CTATCGAGAGGCTGGAGGTCAGGGCGGAGGCGCCTTCTTCAGCCCGAGCCCTGGCAGCAGCAGCCTGTCT TCTTGGAGCTTCTTCTCGGACGCCTCCGACGAGGCAGCCCTGTATGCAGCGTGCGACGAGGTGGAGTCTG AACTTAATGAAGCAGCCTCCCGTTTTGGCTTGAGCTCTCCGCTGCCCTCGCCCCGGGCTTCTCCTAGGCC ATGGACCCCGGAGGATCCCTGGAGCCTATACGGTCCAAGCTCGGGAGGCCGAGCGCCAGAGGATAGCTGG CTACTCCTCAGCGCTCCTGGGCCCGTCCCAGCCTCCCCTCGGCCTGCTTCTCCCTGCGGCAAGCGGCGCT ATTCCAGTTCCGGAACCCCATCTTCGGCCTCCCCAGCTTTGTCCCGCCGAGGCAGCCTTGGAGAAGAAGG TCCAGAGCCACCTCCACCACCCCCGTTGCCTCTGGTCCGGGACCCTAGTTCCCCTGGCCCTTTTGACTAT GTGGGTGCTCCACCAACCGAGAGCATCCCTCAGAAAACTCGGAGGACTTCTAGCGAGCAAGCAGTGGCCC TGCCTCGGTCTGAAGAGCCTCCCTCGTGCAATGGGAAGCTCCCCTCCGGTACAGAGGACTCTGTGGCTGC TCCGGGGGCTCTGCGGAAAGAGGTGGCCGGCATGGATTACCTAGCAGTGCCTTCTCCCCTTGCTTGGTCC AAGGCCCGGATTGGGGGACACAGCCCCATCTTCAGGACCTCTGCCCTACCTCCCCTGGACTGGCCTTTAC CCAGCCAGTATGAGCAGCTGGAGCTGAGGATCGAGGTACAGCCTAGAGCACACCACCGAGCTCACTATGA GACTGAGGGCAGCCGGGGGGCTGTCAAGGCTGCTCCTGGAGGCCACCCTGTGGTCAAGCTCCTAGGCTAC AGTGAGAAGCCATTGACTCTGCAGATGTTCATTGGCACTGCAGATGAGAGGAGCCTGCGGCCCCATGCCT TCTACCAGGTGCACCGGATTACTGGCAAGATGGTGGCTACAGCCAGCTATGAAGCTGTAGTCAGTGGTAC CAAAGTGTTGGAGATGACCTTGCTCCCAGAGAACAACATGGCTGCCAACATTGACTGTGCTGGAATCCTG AAGCTTCGAAATTCAGACATTGAGCTACGGAAGGGTGAGACAGACATCGGGCGCAAAAACACGCGTGTGC GGCTGGTGTTCCGTGTGCACGTGCCTCAGGGCAGCGGGAAGGTCGTGTCTGTGCAGGCAGCATCAGTGCC CATCGAGTGCTCCCAGCGCTCTGCCCAGGAGCTGCCCCAGGTGGAGACCTACAGCCCCAGTGCCTGCTCT GTGAGAGGAGGGGAGGAGCTAGTGTTGACTGGTTCCAACTTCCTGCCAGACTCTAAAGTGGTGTTCATTG AGAGGGGTCCTGATGGAAAACTGCAGTGGGAGGAAGAGGCGGCGGTGAACCGGCTGCAGAGCAGTGAGGT GACATTGACTCTCACCATCCCCGAGTACAGCAACAAGCGGGTGTCCCGACCAGTCCAGGTCTACTTTTAC GTCTCCAATGGACGGAGGAAGCGCAGTCCTACCCAAAGTTTCAAGTTCCTACCTGTGGTCTTCAAGGAGG AGCCCCTACCAGACTCATCTCTCCGGGGCTTCCCTTCCACATCGGGTCCCCCCTTTGGCCCTGACGTGGA CTTCTCACCGCCCAGGCCCCCTTACCCCTCCTATCCCCATGAAGACCCTGCTTATGAGACTCCTTATCTG TCAGAAGGCTTTGGTTATAGCACACCCGCTCTGTACCCCCAGACGGGGCCCCCACCGTCCTATAGATCTG GCCTGCGGATGTTCCCTGAGACTGGGGGTACCACAGGTTGTGCCCGCCTACCTTCAGTCTCTTTCCTTCC GCGCCCTTTTCCTGGTGATCAATATGGAGGACAGGGCTCCTCTTTTGCCCTGGGGCTTCCATTCTCCCCT CCAGCCCCCTTTAGGCCGCCACTGCCTTCCTCCCCACCACTCGAAGACCCCTTCCATCCCCAGAGTGCCA TCCACCCCTTACCTCCTGAGGGCTACAATGAGGTGGGGCCAGGCTATACCCCTGGGGAGGGGGCTTCGGA GCAGGAGAAAGCCAGGGGTGGCTACAGCAGCGGCTTCAGAGACAGTGTACCTATCCAGGGTATCACCCTG GAGGAAGTGAGTGAGATCATTGGCCGAGACCTGAGTGGCTTCCCTGCACGTCCTGGAGAAGAGCCTCCTG CCTGAACCACATGTAGTGGTCCCCGAAGCCCCACCGCCTTGCCCTCTTAACTGGGGTGCTGGCTCCAGAA GCTTGGGGCCAACTCTAGTTTCTCCTAGCCCAGCTTCTAGCTTCCTGTTTTCCCTTTCTCTCCCAGCAAA GGTGTGGCCCCCAGGCCTGGTGCTGCCTTGGAAGGGACTAAGGGTGTGGGGGACAGGGGATGAGGGTGGA GCCTGAGGCTGGAGGCCAGAACTGACTGGGCTGAACATGATGTCCTGATCGTGCAGGCCGTGATGCTAAC AAGCTGGACAGGTTGATGGGTAATAAACTGCTCGCTGACCAGTGAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_023699
• Insert Size: 2706 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC028928, AAH28928
• RefSeq Size: 3075 bp
• RefSeq ORF: 2706 bp
• Locus ID: 73181
• UniProt ID: Q8K120
• Cytogenetics: 14 C3
• Gene Summary: Ca(2+)-regulated transcription factor that is involved in several processes, including the development and function of the immune, cardiovascular, musculoskeletal, and nervous systems. Involved in T-cell activation, stimulating the transcription of cytokine genes, including that of IL2 and IL4 (PubMed:17198697). Along with NFATC3, involved in embryonic heart development (PubMed:12750314, PubMed:17198697). Involved in mitochondrial energy metabolism required for cardiac morphogenesis and function (PubMed:12750314). Transactivates many genes involved in heart physiology. Along with GATA4, binds to and activates NPPB/BNP promoter (PubMed:9568714). Activates NPPA/ANP/ANF and MYH7/beta-MHC transcription (By similarity). Binds to and transactivates AGTR2 gene promoter (PubMed:17198697). Involved in the regulation of adult hippocampal neurogenesis. Involved in BDNF-driven pro-survival signaling in hippocampal adult-born neurons. Involved in the formation of long-term spatial memory and long-term potentiation (PubMed:22586092). In cochlear nucleus neurons, may play a role in deafferentation-induced apoptosis during a developmental critical period when auditory neurons depend on afferent input for survival (PubMed:18354019). Binds to and activates the BACE1/Beta-secretase 1 promoter, hence may regulate the proteolytic processing of the amyloid precursor protein (APP). Plays a role in adipocyte differentiation. May be involved in myoblast differentiation into myotubes (By similarity). Binds the consensus DNA sequence 5'-GGAAAAT-3' (Probable). In the presence of CREBBP, activates TNF transcription. Binds to PPARG gene promoter and regulates its activity (By similarity). Binds to PPARG and REG3G gene promoters (PubMed:17198697).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the longer isoform (1).