Erlin2 (NM_153592) Mouse Untagged Clone

CAT#: MC204139

Erlin2 (untagged) - Mouse ER lipid raft associated 2 (Erlin2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Erlin2
• Synonyms: BC036333; C87251; Spfh2
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC038374
  GTTGCACGGGGGTTCGGCTGTGTACGGAGCGCCTGGAGGGACAGCCTGGATACAGGTTCACTGATGGCTC AGTTGGGAGCTGTTGTGGCCGTGGCTTCCAGTTTCTTTTGTGCATCTCTCTTCTCAGCTGTGCACAAGAT AGAAGAGGGACATATTGGAGTATATTACAGAGGTGGTGCCCTGCTGACCTCCACCAGTGGCCCGGGTTTC CATCTCATGCTCCCGTTCATCACATCCTATAAGTCTGTACAGACCACTCTCCAAACTGATGAAGTGAAGA ACGTACCATGTGGAACCAGTGGTGGTGTGATGATCTACTTTGACAGAATTGAAGTGGTGAACTTCCTGGT CCCAAATGCAGTGTATGATATAGTGAAGAACTATACTGCAGACTATGACAAGGCCCTCATCTTCAACAAG ATCCATCATGAGCTTAACCAGTTCTGCAGCGTTCATACTCTTCAGGAAGTCTATATCGAGCTGTTTGATC AAATTGATGAAAACCTCAAGTTGGCTTTGCAGCAGGACCTGACTTCCATGGCCCCTGGGCTGGTTATCCA AGCTGTGCGAGTGACAAAGCCCAATATACCTGAGGCAATCCGCAGGAACTATGAGCTGATGGAAAGCGAG AAGACGAAGCTTCTCATTGCAGCCCAGAAGCAGAAGGTGGTGGAAAAGGAGGCAGAAACAGAGAGGAAGA AGGCCCTCATTGAGGCAGAAAAAGTGGCACAGGTTGCAGAAATCACCTATGGGCAAAAGGTGATGGAGAA GGAGACAGAGAAGAAGATCTCAGAAATTGAAGATGCTGCGTTCCTGGCCCGGGAGAAGGCGAAGGCCGAC GCTGAGTGCTACACAGCGCTGAAGATCGCAGAAGCAAATAAGCTCAAGCTGACTCCAGAATACCTGCAGC TGATGAAGTACAAGGCCATTGCTTCCAACAGCAAGATTTACTTCGGCAAAGACATCCCCAACATGTTTAT GGATTCCGCAGGGGGGCTGGGCAAGCAGTTTGAGGGGCTGAGCGACGACAAGCTGGGCTTTGGCCTAGAA GATGAGCCCCTCGAGGCACCCACAAAGGAGAACTGAGGAAACACTGTCTGCAAGCTCTGCTCGGGCAGCT TAGAGAGAGCTGTATTCTTTAAGATGAGACAGAGCAAAGCGCTCCTCCTTTCCACACTACCTTCCTTGAC TCTTCTTACTGTGGTTAAAAAGGAAGAAATGGACACAAACTTACCCCCTTCTGGGAAGGGAGAGCAGATG GAGAGTTGTTTTTTGGGTTTATTTTTAATTCAGGTAAGTAAGTTGTATGACTTCTGAGAAGGTGTATGCA CCGTAGATTTGACCTCTGACCTGCAGACACCAACATTGTCACTTTGAAGCTGGTTTAAGTGGAGCTACTG TCAGTATGAAGAGGGAGAGTGTGTGCTGCCTCCTCGTGCTTGAATTCCTTCAGGGAAAAGTGTACTCCAC AGTTCTCTCCCTTGCCTCTAGTGTAGGCAGTGTCTGCGTGTGGGGCTCGTGACAGAAGGCCGTCTGCTGC GGAACATGAGCTGCAGAGAGCGTTGGCCGGCTGGGCTTTTTGACTGAGTGGATTACTTGAGAGTTAAGCT GTCTTGAGCCCTTTTTAGGAAGAACTTGGTGCTAGGTTTTGCAAGGTTTTCTACACACTGTACTCTGCTC TAGTGTTTGTTGGCTACATCTCACCGCAGCAGGGCTTGGTCACACCACACACTCCTTTTCCGTACTTTGA CCTGATCTGTGATTTCATTTCTTCTTGAATAATCTATTCATGAGTTGCACTCAGCGTTAAGATGGGAACA AACAAGTGCTGTTAGCTGATGACGTAGCTCCTTATACCCCTTAGCACTGTGGTGCTGTGTGGCTAATTAT GCGTATGCTTTTGAGACCAAACATCTTTATCATTATGGAGATTCTTCATTGAAGAGCCCTTAACACTGTG GAGAAGGGCCCAGCCAGATGACACCCAAGTAGTAGTGCCTGTGGCCTGTGCTGGGGCTTTGTCTGACACT GATGAAGAGAGCAGGCAGCCACTTGAGAGTCGGCTCCAGTGAGTCACCCTAGGAAACTGAGAATGCGAAG AATAGATATGAGAGAAAGGGATTTCTTATCCTGAAATTGCACTGGGGGTGGGGCTCTACCATGGCCTGTG AGTGCACACAGAATGCCTCTGTGGAGGGCAGCTCTGCAGGTAATCTGCAGACATGGCAGTACCCTGTGCA ACCATGACTGGCTCTAGCTTAGGACTTGGCCTTGTTAGCTGGTCCCCTACCTCATCCTCCCCCCACACAA AGCACCTACTGTTCTCTCTTAGGTGACTACTATAAATGGTATTTTCTGGCATCAATTCCCACCTCAGTTT TGGTTTTGTAAGTCGGGCCAGTTTGCTCCTAAGTGGCACCAGACTTGTCAGGTATTTGGGAAGCATTCAG CCGACCCAAAAAGAGGCAGGGTTCACTGTGCTTACTTCAGATGTTCCCTTCTCTGTCCTGACTCCTCAGG CCACTGACCCTGGCCACACTGTACAAACTACAAAATGTTCCTGAAAAGGACATTTTAATGTGCTCAAAAG CTCTTGCAAAAGTGGGTTTTTTTCCCCAAGACCAACTCATCTTCTTCTCATTTGTTGCTGCTAACCACTT GTTGAGAGCAACGTGCTATACCCAGCATCCTCTCTTGTACGTGCACCTGAGAAAACACTACTTCAGTGGA GTCGGTGCAGGAGGGAGGGTACCCCGCCATCCAGCGCCCTCCTAGCCCGAGAGGCTCTGTAACTAGCATT CTGAGAGCTCATCCCTCCATTACAAAGAGCCACAGTAAAGTCCTGCTGCAGCTGCTCCTTCCCTGCCCCT TTAATGTCACTTCTTTAACAGAACAGAAATGTCCCCATGTCATAGCATAAATTCAGTAGCTATTGGTATC TGTCCCAGCAGTAAAATCATGGAACTCAGATGTCTTTTTAGCATGGGATGCCTAGCCCATCTGTCTTTAT GACCTTGTTTTTTGTAATACTATAAAATCTGACTTAGGCATTTGAATTCTAAACATGTAAAATGTGATAA GCCTGCAGTTTTGTAGGCAGTGAATTCATAGCTGCTATTTTTAAGTAGAACTTCTATCAAAATACGTTAA CCGTTTGTAAAATTCAGTTTTTGTAGGACTTTCCCAAGGCCCAGCCACCTTGGTAGAATGCTTCTCACTC ACTAAATGTTGCAGAAGCAATTTATATTCCATATAGGTTTTTAATCACTTTTCAATATATGGTTAGAATG TTTGTAAGGAAGCCTAAGTTTAATAATTTTTATATAACTAAAAATAGGTGTGGAGGACTCAGTGTGGGTA CTGAGGAGGAATGAAGTGCTCTGAAAAGGGAGGTGTATAAACGGCCTGTGGGGCCGTGTGTCTTGTGAAA GTGAGATAGCCGTGCTTACTGACCTGGGCTGTCGTCAGCTGGCCGTCGGTAAACTACCTGGACAATAGCC CCTCTGTCTGGGAACTTTACCTACTTCCTTGTCCTCAGTGGGCTTCTAGCCACTGTTTGTTTCCTTATAA AAGCTGTAATGGGCAATCATGTGTTTGTACTTCCATTCCTTTTTATCTCTACTTCTGTGTAAACTGGTGA TTGAATAGTTAAAGCAATTTTTTCAGTGTGCCCCAAGGGCATTAATGAGCCTTTATAACTGAGAAATGAT TCTTGTTATAGTAATTATTCCATAAATGATACCACTAGATAAATTACCTTGGGTTAATAGCTCCAGGATT TGTTTCAGACAACAAAAAAAGGTCTCAATGTGAATATACTTACATTTTGGATTTAATTTCAGTCTTGCTA AATAAAATGTTTTTGTCTTTTTTTAAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_153592
• Insert Size: 1023 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC038374, AAH38374
• RefSeq Size: 3892 bp
• RefSeq ORF: 1023 bp
• Locus ID: 244373
• UniProt ID: Q8BFZ9
• Cytogenetics: 8 A2
• Gene Summary: Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. May promote ER retention of the SCAP-SREBF complex (By similarity).[UniProtKB/Swiss-Prot Function]