C2 (NM_013484) Mouse Untagged Clone

CAT#: MC203786

C2 (untagged) - Mouse complement component 2 (within H-2S) (C2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: C2
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC011086
  TTCCGATCTCGGGGAAGTCAGATGACTTTTCCTCTCCCCTAGCTCTCCGTTCTACTGTCCTGGAGACCAT GGCCCCTCTGCTGGCTCTCTTCTACCTGCTGCAGCTGGGCCCAGGCCTGGCTGCTCTCTTCTGCAACCAG AATGTCAATATCACCGGTGGTAATTTCACCCTCAGCCATGGCTGGGCCCCTGGGAGCCTCCTCATCTACT CCTGCCCCCTGGGCAGGTACCCGTCCCCAGCCTGGAGGAAATGTCAGAGCAACGGACAGTGGCTGACACC AAGGTCTAGCTCACATCACACCCTGCGATCCTCTCGGATGGTTAAAGCAGTCTGCAAACCGGTTCGATGC CTAGCTCCTTCATCCTTTGAAAATGGCATCTATTTCCCTCGGCTGGTGTCCTACCCTGTGGGTAGCAACG TGAGCTTTGAGTGTGAGCAAGACTTCACCTTGCGGGGCTCACCTGTGCGGTACTGTCGCCCCAACGGCCT GTGGGATGGAGAGACGGCTGTGTGTGACAATGGGGCTAGCCACTGCCCCAACCCTGGCATCTCAGTGGGC ACAGCTCGGACAGGCTTGAACTTTGACCTTGGGGACAAGGTCAGGTACCGCTGCTCCTCCTCAAATATGG TATTGACTGGCTCTGCAGAGCGGGAGTGTCAGAGCAATGGAGTGTGGAGTGGGTCGGAACCCATTTGCCG ACAGCCTTACTCTTACGACTTCCCTGAGGATGTAGCATCTGCCCTAGACACCTCCCTCACCAACCTGCTT GGAGCCACCAATCCCACCCAGAACCTTCTGACAAAAAGTTTGGGCCGTAAGATCATAATCCAGCGCTCGG GTCACCTGAACCTCTATTTGCTGCTTGATGCTTCTCAGAGTGTGACAGAAAAAGACTTTGACATCTTCAA GAAGAGTGCCGAACTCATGGTGGAGAGGATCTTCAGCTTTGAGGTAAATGTCAGCGTAGCTATCATCACC TTTGCCTCTCAGCCCAAAACCATCATGTCGATCCTGAGTGAGAGATCCCAGGATGTGACGGAGGTGATCA CCAGTCTGGACTCTGCCAGCTACAAAGATCACGAAAATGCCACTGGCACTAACACTTATGAGGTTCTCAT CCGCGTTTACTCCATGATGCAAAGCCAGATGGATCGCCTGGGCATGGAGACCTCTGCCTGGAAGGAAATC CGTCACACCATCATCCTTCTGACTGACGGAAAGTCCAACATGGGTGACTCTCCCAAGAAAGCAGTCACCA GAATCAGAGAGCTCCTGAGCATCGAACAGAACAGAGATGACTACCTGGACATCTATGCTATTGGGGTGGG CAAGCTGGATGTGGACTGGAAAGAACTGAATGAGCTGGGTTCCAAGAAGGATGGCGAGAGGCATGCCTTC ATCTTGCAGGATGCAAAGGCCTTGCAACAGATCTTTGAGCACATGTTGGATGTCTCTAAGCTCACAGATA CCATCTGTGGGGTGGGGAACATGTCCGCCAATGCCTCTGACCAGGAGAGGACACCTTGGCAAGTCACCTT TAAGCCCAAGAGCAAGGAAACTTGCCAGGGATCACTCATCTCTGATCAGTGGGTGCTGACAGCAGCTCAC TGCTTCCATGACATTCAGATGGAGGACCACCACCTGTGGAGGGTCAATGTAGGTGATCCCACCTCTCAGC ATGGCAAAGAATTTCTTGTGGAGGACGTGATAATTGCCCCAGGGTTTAATGTCCATGCAAAGCGGAAGCA GGGCATCTCAGAGTTCTATGCTGATGACATTGCCTTGCTGAAGCTATCTCGGAAAGTGAAAATGTCCACC CATGCCAGACCCATCTGCCTTCCTTGCACTGTGGGAGCCAACATGGCTCTGCGGAGATCCCCAGGTAGTA CCTGTAAAGATCATGAGACAGAACTTCTGTCACAGCAGAAAGTTCCTGCACATTTTGTAGCTTTGAATGG GAACAGACTCAACATCAACCTCAGGACAGGACCTGAGTGGACAAGGTGTATCCAGGCTGTCTCCCAAAAC AAAAACATCTTCCCCAGCTTGACAAACGTTAGCGAGGTGGTGACAGACCAGTTCCTATGCAGTGGGATGG AGGAGGAAGATGACAATCCTTGCAAAGGAGAATCTGGGGGAGCCGTTTTCCTTGGACGGAGATACAGGTT CTTCCAGGTGGGCCTGGTGAGTTGGGGTCTTTTTGACCCTTGTCATGGTTCCTCCAACAAAAACTTGCGC AAGAAACCTCCACGTGGTGTTCTGCCAAGGGACTTCCACATTAGTCTTTTCCGCCTGCAGCCCTGGCTGA GGCAGCACCTGGATGGTGTCCTGGACTTTCTGCCACTTTAACATGGTCACTGACTCCTTTATTAGTCTGA ACTTCCTGTCTAATACCTCTGAGCGTTCTCACTCCTGGATACATAAATCTTGGGCCCCGGGAGCCCAGAG ACAGTGGCAAAAGCTAGGGAATCCCCAGGATTGTGCCGGGACCTCTGTGCCACCTGTGAAGCAAGTCTCT CTCTAGTGTGGATGACCCGTGCTCCTTTTGCTTTCACACGGAATTTCCCAGTTATGTAATTAATAAAAAT CAATGATTTCCAAAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_013484
• Insert Size: 2283 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC011086, AAH11086
• RefSeq Size: 2618 bp
• RefSeq ORF: 2283 bp
• Locus ID: 12263
• UniProt ID: P21180
• Cytogenetics: 17 18.41 cM
• Gene Summary: This gene encodes component C2 of the classical pathway of the complement system. The encoded protein undergoes proteolytic processing mediated by component C1 resulting in C2a and C2b fragments. C2a fragment, in turn, selectively cleaves components C3 and C5 of the complement system. Mice lacking the encoded protein are found to be more susceptible to bacterial infections. Mutations in the human homolog of this gene are associated with disorders such as systemic lupus erythematosus, Henoch-Schonlein purpura, or polymyositis. [provided by RefSeq, Mar 2015]