Rhbdd1 (NM_029777) Mouse Untagged Clone

CAT#: MC203669

Rhbdd1 (untagged) - Mouse rhomboid domain containing 1 (Rhbdd1), transcript variant 1, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Rhbdd1
• Synonyms: 4930418P06Rik; mRHBDD1; RRP4
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC005518
  CTTAGAGAGAGTGCAGTTCTCCGTGTACCTCCCTGGGTTCCTAATCCTCTAGCACAGATCCTTATCCACG CTCCTGATATCCTGCAGTCATGCAGCGGAGAACGAGAGGGATCAACACCGGCCTCCTCCTGCTCCTCTCT CAAGTGTTCCAAATTGGGATCAACAACATTCCGCCTGTTACCCTCGCAACCTTGGCTGTCAACGTCTGGT TCTTCCTGAATCCTTGGAAGCCCCTGTACCATTCCTGCATCAGCGTGGAAAAGTGTTACCAGCAGAAAGA CTGGCAGCGTTTACTGCTCTCTCCCCTGCACCACGGAGATGACTGGCATTTGTATTTCAACATGGTGTCC ATGCTCTGGAAAGGTGTGAAGCTGGAGAGAAGGCTGGGAAGCCGATGGTTTGCCTACGTGATCGCCACCT TCTCCCTGCTTACGGGGGTGGTGTATTTGCTCTTGCAGTTTACTGTTGCCGAACTCATGAATCAGCCTGA CTTCAAAAGGAACTGTGCTGTGGGCTTCTCAGGAGTTTTGTTTGCCTTGAAAGTTCTTAGCAACCATTAC TGCCCCGGAGGCTTTGTCAACATTTTGGGCTTTCCTGTCCCCAATAGATTTGCTTGTTGGGCAGAGCTGG TGGCCATTCACTTCTGCACCCCAGGGACTTCCTTTGCTGGGCACCTGGCCGGCATTCTGGTTGGACTGAT GTACACGCAGGGGCCTCTGAAGAAAATCATGGACATGTGTGCAGGCATTTTTATCTCCCACTCTGGGCCT TCAGGACAGCAGAACCACTTTAACAATGCAGGCCCCTCCGGATATCAGAATCACTATGCAGATGGCAGAC CAGTGACCTATGATGCAACTTACAGGAACTATGATGTCTACACAGCGGGCCTGAGCGAGGAGGAGCAGCT GGAACGAGCATTAAGAGCCAGCATCTGGGACCGAGGAAATACCAGAAATGGTCCAATGCCGTATGGCTTC CGGCTCCCACCAGAAGAAATGAGGAGACAGCGTCTTCACAGATTTGATGGCCAGTGATATGGCACCATGC AGGGGAAGTCCAGCTGTGCGATTGGAGCCCGTTCACTTAACTCCCCAAGCCCCTAATTGGTTTTAAACAA AAGAAGAGCACAGGGTTACTGTTGCAGGTCACTCTTGTCTGCCATGAACAAGTACTCCATGGCCCCTGTG TGCCCAGATGCACAAGCCCAGCTGACATGTCCCAGGAAGCCCACAGCCTTCCCAGAGTGGCCTGTCTAGC CCCGTGATCGCTCCTAAACCGAAGGTCACCTCTTCAGATGGGACCAATTTCCATTTTTCTCCTTCCCTCC AGACTCAGTGGCTTATCCACACTGCGGTGAAGCCTGGGCCCTTAATAGGAAGTGGGTTCTTTATCTCACC AGGTGAGTGGATCAGCCCTCACTCTGCCTGGCATGCCAGGTTCTTGGCTTAGCAGGAGGGGCAGTGCTAC CCCTGGTCCTCCCACCATGTTTCCATGGTGATGCGGGAAGAGGATGTGGCTACCTTCCCAGGGCGTTCCG TTCTCTTTCACGCAGGCTCCTCCGGGTGCTCAGGCTACCAAGTCTGCCTGATGTTCACATCTCCTGCCTT ATTCCACATGTAGAATGTCTAACAGGAGGGGAATAAGAAAGATCTAAGGTAGGAAAAGAACCCAACTCAC TCATTAGATATCATTGTGGCACCAGCAATTTGGGTTCAGAGCCACCCCCTCCAGGAGCGGGCGACTTGTT TAACTGCTCCACAGAGCGGCAACAGGTGCCACACACACACAGAGCAAAGCCAACATGTTGAGTGGGGTTC TCACAGGGAATCCCCCTTGCAGCAAGTATTTTTTTTTTCCTTCATGAAAGTGCCTTCTCATTGGCTACTC TGGCTGTAGTTGGTCATAAACAAGTGTGTGAAAAATGCCCCAGGGAAATGCTGTGTCGAGTCACTTAAGG CATTTCTGTTTCTTGTGTTCTGAGAATAAAAAGGCAAAGACAGGGTGTTGCCACCTCCTCACAGTCAGGG AGGATTTAGATCAAAGGGAGTTAGGAGCAACAAATGGTGTTCCTCCGACTCTTATGCACCCTCCCTGCAT AGTTTCCAATGAGAATGGGTGTAGACAGGCTTTCCTATGCACAACGCACGCACACACCTAGGATGGAATA CTAAGTGGCGATACCCATCAGCTCTGGGGGACAGGCACATAGGACCTGACTTTCTTTGTTTACAGTTTTA TATTCTATTTTTTAAAGCGTGTGTGCAAGTGTCTGCTGCTTTCAGAAGATTACTTTATACAATGAATCAA GAAACATGTAGCCAGTAAAACAAACCCTAAGCTAAGTACGCTCTGTCCATTAAGAAAAATCATAGACTGG GCATGGTGGCACACATTTCTAATCCCAGCACTCAGGATTCAGAGGAAGGAGGATCTATGAGTTCAAAGCC AGCCTGGTCTACATATGGAGTTCTAAGCCAGCCAGAACACACACACACACCCTTATACACCAAAACCCTG TCTCAAAAAAGAGGGAGGAAGAGTGGGGGGGGAGAAGGAAGATGATGAAGGAAGGAAAGAAATCACAGTA TTTAAATAAAGGTACAACTGCTCATTTTTAAAAGGCACTGGTGCCCAAGGCCAACATTTCAAGGCTATTA ACATCTCAGTTTCTGCTGTATGCATTTGACACATCTGGTGCATGCCATCTGTGTAGCTCCATGCCCACTT GTTAATATGGACCCACCTGGAATGTCTATAACCCGTGCATATGAATGGACTAAGCAAATCCATGGAGTCT AAGCATTCAGACAATGGTGCCTGAGCACCTTAGTTTAATTTGTAATTGGTGGAAAGCCACACCTAGTTGA TATTATAAATTATGCCCATGAGCCTGGTACCTCCAAACACATTTAAATTATAATGGTCAAGGTAAATTAT CCCTGGCTCTCAGGCTGTACATTTGCCTTCCATACCACAATGAGAAACAACCTTTTCCCTACTTGACACC TTTTGATAACACCTGGGAATTCTACCCTAACACTCTTATGTCACTATTCTTATTTGTGCATACCTGCACC AAGTCATGTCTGTGGTTCTGAGTGACCCTAGACCACGGCCTGTTACTGACCTTCAACCTTCCCAGTCTCC CTCCCTCCACACTCAAAAGGCTCAGTAACTGTTATTTTCCCACCAAAGTTATTATTCACTTGTTATTAGA ATTCTGCTAGCTTGTACATGTAGCTTTAATGTAGTAACAGTACCTGGTTGCTTTGTTTGACTTGATGGTC AAAGACACTGAAAATCCCAATTTTGGATGGTGTAGTTATAAAATGCACTTTTTCTTTATTTATGGAGTGG GATGTCACCAAATGTTTATTACAGATGTGGGAAAAGTCATTTTAGGGATAAGTGAAAACCACATGTCTTC CAGAATAAAGATGGTCTGGAAATGATAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_029777
• Insert Size: 948 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC005518, AAH05518
• RefSeq Size: 3471 bp
• RefSeq ORF: 948 bp
• Locus ID: 76867
• UniProt ID: Q8BHC7
• Cytogenetics: 1 C5
• Gene Summary: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the more frequently occurring transcript. Variants 1 and 2 encode the same protein.