Fzd7 (NM_008057) Mouse Untagged Clone

CAT#: MC202423

Fzd7 (untagged) - Mouse frizzled homolog 7 (Drosophila) (Fzd7), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Fzd7
• Synonyms: Fz7
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC063077 sequence for NM_008057
  GGCGGGCGGTGCTGGACGCGGAGAGTCGCGGGCCGGGAGGACTCTCATGCGCCGGGCGCGGCGGCGCCTC CCTGTATCCAAGCCTCTCCCCAGCGCCTCGTCTTTTTCCTCCAGCTGAGAACGCCGCTGCACTCGCGACC GGCGATGCGGGGCCCCGGCACGGCGGCGTCGCACTCGCCCCTGGGCCTCTGCGCCCTGGTGCTTGCTCTT CTGTGCGCGCTGCCCACGGACACCCGGGCTCAGCCATATCACGGCGAGAAAGGCATCTCGGTACCGGACC ACGGCTTCTGCCAGCCCATCTCCATCCCGTTGTGCACGGATATCGCCTACAACCAGACCATCCTGCCCAA CCTGCTGGGCCACACGAACCAAGAGGACGCGGGCCTCGAGGTGCACCAGTTCTACCCTCTGGTAAAGGTG CAGTGTTCTCCTGAGCTACGCTTCTTCTTATGCTCTATGTACGCACCCGTGTGCACCGTGCTCGACCAAG CCATTCCTCCGTGCCGTTCCTTGTGCGAGCGCGCCCGACAGGGCTGCGAGGCGCTCATGAACAAGTTCGG CTTCCAGTGGCCAGAGCGGTTGCGCTGCGAGAACTTCCCAGTGCACGGTGCCGGCGAGATCTGCGTGGGG CAGAACACGTCCGACGGCTCCGGGGGCGCGGGCGGCAGTCCCACCGCCTACCCTACTGCTCCCTACCTGC CAGACCCACCTTTCACTGCGATGTCCCCCTCAGATGGCAGAGGCCGCTTGTCTTTCCCCTTCTCGTGTCC GCGCCAGCTCAAGGTGCCCCCCTACCTGGGCTACCGCTTCCTAGGTGAGCGTGACTGCGGTGCCCCGTGT GAGCCGGGCCGTGCTAACGGCCTCATGTACTTTAAAGAAGAGGAGAGACGGTTCGCCCGCCTCTGGGTGG GTGTGTGGTCAGTGCTGTGCTGCGCCTCGACGCTCTTCACGGTGCTCACCTACCTAGTGGACATGCGTCG CTTCAGCTATCCAGAGCGACCCATCATCTTCCTGTCGGGTTGCTACTTCATGGTGGCAGTGGCGCACGTG GCAGGCTTCCTGCTAGAGGACCGTGCCGTGTGCGTGGAGCGCTTCTCGGACGATGGCTACCGCACGGTGG CGCAGGGCACCAAGAAGGAGGGCTGCACCATCCTCTTCATGGTGCTTTACTTCTTCGGTATGGCCAGCTC CATCTGGTGGGTCATTCTGTCCCTCACTTGGTTCCTGGCAGCTGGCATGAAGTGGGGCCACGAGGCCATC GAGGCCAACTCGCAGTACTTTCATCTGGCCGCGTGGGCTGTGCCAGCGGTCAAGACAATCACCATTTTGG CCATGGGCCAGGTGGATGGTGACCTACTCAGTGGAGTGTGCTACGTGGGCCTGTCTAGTGTGGATGCATT GCGGGGCTTCGTGCTGGCGCCCTTGTTCGTCTACCTCTTCATCGGGACGTCCTTCCTGTTGGCCGGCTTT GTGTCTCTCTTTCGCATCCGCACCATCATGAAGCACGACGGCACCAAGACAGAGAAGCTGGAGAAGCTGA TGGTGCGCATCGGCGTCTTCAGCGTGCTCTACACGGTGCCGGCCACCATCGTGTTGGCCTGCTACTTTTA TGAGCAGGCCTTCCGAGAGCACTGGGAACGCACCTGGCTCCTGCAGACTTGCAAGAGCTACGCTGTGCCC TGCCCTCCGGGCCACTTCTCTCCCATGAGCCCCGACTTTACAGTCTTCATGATCAAGTACCTGATGACCA TGATCGTGGGCATCACTACGGGCTTCTGGATCTGGTCGGGCAAGACCCTGCAGTCATGGCGTCGCTTCTA CCACAGACTCAGCCACAGCAGCAAGGGGGAAACTGCGGTATGAGCCCCGGTCCTTACCCACCCTTGCCTC TTCTACCCTTTTACAGGAGGAGAGGCATGGTAGGGAGAGAACTGCTGGGTGGGGGCTTGTTTCCGTAAGC TACCTGCCCCCTCCACTGAGCTTTAACCTGGAAGTGAGAAGTTATTTGGAGGTGAGAAGAGATTTGGGGC GAGAGATGGTTTTGAGAGGAGGCCCAGATGAAAAAAGGCAAAGGCAGTGGCCGAAAAGACTTCTGGCTAA GACTTGCAGGACGATGCTAACTGTGAAAGATATGGACCGGCTAGGGCCTAAGGGAAAGGTTGAGACCAGC AGAGAGAGAGACTGGTGAGGTTTTCAGGCGCCAGAGATGAGCCAGGGCTGTGAGTCCAATCCCCTGCTGC AAGGCAAGTGGTTGTTCTCACTCTAGTGAAGGGGGGCTGGGAGGGGAGGGTGATACCGCTCTGTCTGTAG CCTAGGCTTTGTGGCCAAGATGGGGGGGACCTCCTGCGGTGCCCTTGTCAAGTGGTGGTCAAACCATAAT CTCTTTTCACTGGGGCCAAACTGGAGCCCAGATGGGTTAATTTCCAGGGTCAGACCTTACAGTCCTCCTC CCGGGCCCCCTCCCGCCTGCTTTTCCTTCCCTACTCCTTTCAAGTCTAGTAAAATAAGCATTTGGAAGGC CGGGCCCTGCCTGCTAGAGTCCTAGCGTGAAGTTGGTTTTCAAGAGGAGGCCAAGAAGGCGAGTGGGAGA TACAGTCTGCTACTTTTTAATTTGTTGCTACTTTTTCATTTTCTAGGGAAGGCAGAGAGAAAAAGAATGT TTTATTTGGTTTCATACCCTGAAAAAAAGTCATGACTTGTTGCTTTTCAAAACAGGAACGCATTCACACA CACACACACCCCATCCCACCCCCCTTGTCTTTGTTGTAAGAGACAAAGCGGGAAACAAAAGTGTCTCCCT GAGGAAAGGCCTAACTGTGAAGCCAGCAGCTTTTACAGGCAAAGCCACAGAAATCCGAGGTTTTCCTTTG GTTGTTAATTTGGTTGAGATAAACATTCCTTTTTAAGGAAGAGTGAAGAGCAGCTTTCATACCCATTCAG GCACACGTTCTGACTTGGATAAAGGAAATGCTAGGAGTTTTGTTATTTGTTTTAAACAGATTTAATTCAG AACACATGATCTAATAGACTCTTTTGCTTAATGAAATCTCCTCCCATTCTACGCCCCCATAACCCAAATT TTGATTTTTCTGCCCCCTTCCTTCCGTCCAATTTGGGATTTTTGCTGTTTTTGTTTTGTTGTGTTTTGTT TTTCCTCCAGACAGGGTATCTCTGTGTAGCCCTGACTATCCAGGAACTGGCTCTGTAGAGCAGGCTGGCT TTGAACTCACAGACATCCACCTGCCTCTGCCTCTCAATTGCTGGGATTAAAGGCATGGTCCACCAGGCCT GGCTCCCCTTCCTAATTTGTATCTTTCAAGACATAACGCTCACATTAGTAAAGATAAAAGACAAAAATTT TAACTTAAAGGTTTAAAAGCATTTTGCCCTCATTTTCTTGTTCTAGAGATGTAAACATCTATCTATCAGA CACATGAGCTGACCCTTTCTCTCTCTGGTTGCATGAGGCGAGGGCAAGAGGAATGATAGCGAAGGAAGAG GAGAGTTTGAGTCAGGTTTCAAGAAAGTCATTAAGGGAAGGTGAACTTCAAAGTGATTCTGGAGTTCTTT GAAATGTGCTAGAAGACTTACATTTATTAATCTTAAATCGTGTACTTCTCTTTTTTTCCCTGCAATAGAA GTCTGGTTCTTTGGCATAATGTAAAGCTGAGCAGAGCATCATGGGAGTTGACCTTTACCCTACCTTTGAC ACTGACTGTCCTCCAATTTTGCAATGTTCTTCAGTTTCTCAGAGCAGTTTTTAATGCCAGCCAGGGGGGG ATTGTCGGGAGGACAGATTACTTCATATGTGTCCTGTTCAGTTGAATGGAGCTGCTTTTACAATTAAAGT GATCTTGTATTTTTTAAACTTTCAAAGTGATCTCACCTGTCAGAATTTTTTTAAGCTGCCACTACACAGG TTTGGCATCTTTTGTGTTTTATCTCTTTAAGTGCATGTGAAATTTGTAAAATAGAGACAGTGCAGTATGT ATATTTTGTAAATCTCCCATTTTTGTAAGAAAATATATATTGTATTTATACATTTTTACTTTGGATTTTT GTTTTGTTTACCTTTAAAGATCTACAATGAAGCCCCACTTTATCACATGTACAGATCACGAATAAATTTT TTAAAAAATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: AscI-NotI
• ACCN: NM_008057
• Insert Size: 1719 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC063077, AAH63077
• RefSeq Size: 4171 bp
• RefSeq ORF: 1719 bp
• Locus ID: 14369
• UniProt ID: Q61090
• Cytogenetics: 1 30.08 cM
• Gene Summary: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt8 induces expression of beta-catenin target genes.[UniProtKB/Swiss-Prot Function]