Cav1 (NM_007616) Mouse Untagged Clone

CAT#: MC202054

Cav1 (untagged) - Mouse caveolin 1, caveolae protein (Cav1), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Cav1
• Synonyms: Cav; Cav-1
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC052859 sequence for NM_007616
  AAGAGGTAATCCAGCCACGCGCCAGCATGTCTGGGGGCAAATACGTAGACTCCGAGGGACATCTCTACAC TGTTCCCATCCGGGAACAGGGCAACATCTACAAGCCCAACAACAAGGCCATGGCAGACGAGGTGACTGAG AAGCAAGTGTATGACGCGCACACCAAGGAGATTGACCTGGTCAACCGCGACCCCAAGCATCTCAACGACG ACGTGGTCAAGATTGACTTTGAAGATGTGATTGCAGAACCAGAAGGGACACACAGTTTCGACGGCATCTG GAAGGCCAGCTTCACCACCTTCACTGTGACAAAATATTGGTTTTACCGCTTGTTGTCTACGATCTTCGGC ATCCCAATGGCACTCATCTGGGGCATTTACTTTGCCATTCTCTCCTTCCTGCACATCTGGGCGGTTGTAC CGTGCATCAAGAGCTTCCTGATTGAGATTCAGTGCATCAGCCGCGTCTACTCCATCTACGTCCATACCTT CTGCGATCCACTCTTTGAAGCTATTGGCAAGATATTCAGCAACATCCGCATCAGCACGCAGAAAGAGATA TGAGGGACATTTCAAGGATGAAAGGTTTTTTTCCCCCCTTACTATTTCCTTGGTGCCAATTCCAAGTTGC TCTCGCAGCAGCAAATTTATGAATGGTTTGTCTTGATCAAGAACAAAGAATTCATTCCCACCATTCTCAT ATATACTACTTGTCTCTTCTAAGCTACTGCATCTATGTTTGACAGTCTGGAATGTTTAAACCCATTCCTG CTCTCTCTTTTATATGTGAATCATTGTTTCATTGGCTAAAATATAAACATATTGTTGAAATATGATTTGA GAAAAATAGGAAGGACTGGGAGGCAGGGAAGAGTACCAACAACCTCAACTGCCTACTCAAAGGTGATGAT GTCATACAAAGGGAAGAGATTCAGGTTACGGCCATTTGTTTAGGGGCATGAAGGAACGTTTTTAATATAT GCCAGTTATCTAAGGAATTGGTTGCTGTCCTCACTCTTAACAATCCAGTTAGATTTAGGGATTTAGGGAT CACCATCAATTTGGAGACTATAATCTTCATGATACCAACAATGTTTTACTTATCCTGGCATTTTAACCTG TTATTTTGTATGCCTGAATATTTGCTATACTGAGAATAAGACCTACGTGCCTTCTAATTTTTCATGTTTT TTTTTTTCCAAATAGGATCTAACTCATCTACTTGCATGATGCCGGCAGCTTTCCTAAAAACAAAACATAC AAATTGCACTTGCTAGTTCTCTGTACTTGTTTCTGACTCTGAAATACAGAACCTGTTGATGTTGATATCT GTGCTCAGCTATGTAGCATCTTTCTCTCTGTTAAGCCTGGTCAACATTAACCCAATGAAATGATTTGGAG CAGACAAATGGGGGTGAGACCTCTCTGGACTGGCAGAAGTAGAAGCCAGCTTTCCCTGCCACTCAGCAAC TGAATGAGGCCAGCGTGTCTATTCAGTTTCACTCATTTTCAAGAATAATCACAGGTTCCTGACTCTAAGC CAGCCCCTCACCAGGATCAAGGTTTAGTGACTGACTGGGATGATTTAGGAGCTCAACATTGTACTTCCTT TTCAGCTGATGAGTGAACCTCCAGGGAGGGGTGTCAAAAAGGAGGCTGCTAAACCGAGACTGCCAAGCCT GTTGTAAACATGACCCCTTTTATGCAAAGCCCTTGCAATAGTCTGCAATGCTGTGAAGCTCGACCTTTCC CCCTGCAAGGAACCTTTGACCTAATCCAACCATCATTTTGTTCAGAAAGGTGGGGGAAGGGTGGTAACAA AAGCTTGAGGTAATGTTCTTGCTGGAATAAATTCAAGTTTTTCTGAACCCAAACTGAGGAATTTCACCTG TGTACCTGAGTCTCCAGAAAGCTGCCTGCCTGGGACACCCAAAAGCCTTTTACTTCCCAGCTCACATTAC AGCTCTGCCCTTGGGGATATTTTTAAAATTCCAGATAGGCTTTTATTTTCACTTTCATACATGTATTGGA ACCCTGCTTGACTTGTTTTCTCCTTCAGTCTTGCCGACACTTTACCAACCTGCTACCTACTTTGATTGAT TGCATTTAAAACAGACACTGGCATGGCCACAGTTTGAATTTTAAACTGTGCACATAACTGAAAGTGTACT AGACTGTATACCTTTTTACATGTAGAGATATTCTTTATCTTTATATAAGGAGAATCACTTGGGAAGTGAT TCTACAATTCAGTCTGTAAACTGCGTGTTCCAAGACATGTCTGTTCTCCCTAGATACTCAGTTTTATACA AGTCAATTGCTGATCCAAAAGGTTACTGAAATTTTATATGCTTACTGATATATTTTACACTTTTTTATGC TGCATGTCCTATAAAGATTTCAAATCTGCACAATAAAATTGTTTAACAGTTAAAAAAAAAAAAAAAAAAA G
• Restriction Sites: RsrII-NotI
• ACCN: NM_007616
• Insert Size: 537 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC052859, AAH52859
• RefSeq Size: 2451 bp
• RefSeq ORF: 537 bp
• Locus ID: 12389
• UniProt ID: P49817
• Cytogenetics: 6 A2
• Gene Summary: May act as a scaffolding protein within caveolar membranes (By similarity). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19546242). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (PubMed:10816572). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) encodes the longest isoform (1).