Mtmr6 (NM_144843) Mouse Untagged Clone

CAT#: MC201222

Mtmr6 (untagged) - Mouse myotubularin related protein 6 (Mtmr6), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Mtmr6
• Synonyms: 4022440C11Rik; AI428804; AU041072
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC020019 sequence for NM_144843
  GTCACCGCCCCGTTTCTCTCCCGATGGTGCTCTCCTGAGGCCAGCTGCCTGCGGGCGTCGCCCCGGGATG GAGCACATCCGGACAACCAAGGTTGAACAAGTAAAGTTACTTGACCGGTTTAGTACCAACAACAAGTCAC TGACAGGAACACTGTATCTTACGGCCACACACCTATTATTTATTGACGCTCAGCAAAAAGAAACCTGGAT ACTACACCACCATATTGCCTCTGTGGAGAAACTTGCTCTGACCACTTCTGGATGCCCACTTGTGATTCAG TGCAAGAACTTCAGGATTGTGCATTTCATTGTTCCCAGGGAAAGAGATTGCCACGATATTTATAACTCTC TCCTGCAGCTATCAAAACAAGCAAAATATGAAGATCTCTATGCCTTCTCTTATAATCCCAAGCAAAATGA TACTGAACGACGGAATGGTTGGCAGCTTATTGACCTTGCTGCGGAGTATGAGAGGATGGGAGTGCCCAAT GCAAACTGGCAACTGTCGGATGCCAACCGAGAGTACAAGGTCTGTGAGACTTATCCCAGAGAGCTGTATG TTCCTCGGACAGCTAGCCGGCCGGTGATCGTGGGCAGTTCCAACTTCCGGAGCAAGGGCAGACTTCCGGT CCTATCCTACTGCCGGCAGGGCACTGAGGCTGCCATTTGTCGATGTAGTCAGCCATTGTCAGGCTTCAGT GCCAGGTGCCTAGAGGATGAGCATTTGCTTCAAGCCATTAGTAAAGCCAACCCAGGAAACCGCTACATGT ATGTTGTGGATACCAGGCCCAAGCTCAATGCAATAGCTAACAGAGCAGCTGGAAAAGGTTATGAAAATGA AGACAACTATTCTAATATTAGATTTCAGTTCGTTGGAATAGAAAATATTCATGTCATGAGATCCAGCCTT CAGAAATTACTGGAAGTGAATGGTAGCAAGGGGCTTTCTGTCAATGATTTCTACTCTGGTTTGGAAAGTT CAGGATGGCTTCGCCATATCAAGGCTGTTTTGGATGCTGCAATCTTCTTAGCCAAAGCAATAGTGGTTGA AAATGCAAGTGTGTTGGTCCACTGTTCCGATGGGTGGGACAGGACCTCCCAAGTGTGCTCCCTCGGCTCA CTGTTGTTGGATTCCTACTACAGGACAATGAAAGGATTCATGGTTTTAATAGAAAAAGATTGGATATCAT TTGGGCATAAATTTTCAGAGAGGTGTGGCCATTTGGATGGAGACCCGAGGGAGGTCTCACCAGTGTTCAC TCAGTTCTTGGAGTGTGTCTGGCACCTGACTCAGCAGTTCCCACAAGCCTTCGAGTTCAACGAAGCGTTT CTTCTTCAGATCCATGAGCACATTCATTCATGCCAATTTGGGAACTTCCTTGGCAACTGTCAGAAGGAGA GAGAGGAACTCAGGTTAAAGGAGAAAACTTACTCCCTGTGGCCTTTTCTTTTGGATGACAAAAAGAAGTA CTTAAATCCTCTCTACAGTTCCAAATCTCAGAGACTGACAGTCTTGGAGCCAAATACAGCCTCTTTCAAT TTTAAGTTTTGGAGAAACATGTACCACCAGTTTGATCGGACGCTCCATCCTCGGCAGTCTGTGCTGAGCA TAATTATGAATATGAATGAGCAAAGCAAGCAGTTAGAGGAAGACATTAAAGACCTCGAGGCTAAAATTAA GCAATGCAAAAATGGCATCCTAACGAAGGAGTTGCTGCATGCTGTCCACCCTGAATCACCTGCCCTGAAA ACCTCGCTGTGTCTCAAAGAGCCGAGTCTGCTTCCCGTGAAGGACACACTCCGAGCTATAGAGGGCAGCA GCCCAGCAGATAATCGCTACTGTGACTATGCCGAGGAATTTTCTAAGTCGGAGCCTACCGTGGTCAGCTT GGAGTACGGGGTGGCCAGAATGACTTGTTAGCCTCCTTCCGTGATCCCTGGATGACTGTAGTGTAAGAAA TGTATAGTTGTGAGGATGGTCTGTACACATGGGCAGGAGGGGTTGTTGAGTGACTTTGGGGCTTAGCAGT AAGTGAGAAAGTAGGTAGCTGAGAAAAGGATCATAGCAACTCTTGAGAGGAGTGAGTCAGCTAAGTGCCA TTTGTAACAAGAACATACTCATTTCTGTAGGAAGTGAGTGCTAGTGTGTGTATGTACTGGAAAGGGGTTA CACAGGACTGGTGAGCTGACAGTCTGTTGATTCAGATGTTAATTCCAGCCACGCTCAGTAGCTTTCCTCT AACTCTGAGAAAACAGACCTGACAACCTGAACCCTCAGTGACTGATGTGGCATGTGCTTTCAGTTCTGGA GCTGTGTGACTGTGGATTTTGCAGTCACAAAAATCCAAATATATAGTCAAAAATATAGTGACGTTTTAAC ATTAAAGTGCCATGAAAAGTACTTATGGGACAGCCTTAAAGTAGACTCTCAGTTTATTCTGTGGGTTTTA TAGCCGAGGACAGGATGTTTGATCTCTCCTTTAATCAGCCTTATTTCATATGAAGAACTAACTGCACTCT GATTACTTGGGGGCCGCACACTGCAGTGCTCCACCATGGAAAGTTGTAGACATACTCTGCTAGTTTGTAA TTAGCCAGCTCCACCCGTATTTAAAATCAGTGTTACCGAAGGCTTTGTTCTCGTTGTCATTTGTTCCAAG CTGCAGCTGACAGTTCATTATTCACAGCTTAGAGGACTCATTTCTTAGGCTAGTATAAGCACATTTGGCA TTTACTTTCGGCTTACTGCAGTCTATTAATTCTTACTCTGTGGTTGGCTTTAATCCTTTGATAACTGTAC ATTTAAAGTGGCAAAGCTCTAAAGCGTTCTGAGTACTAAATACATTTTTAACTTGACTGTAGCTGCCTAT AAACTTTCAGGTAAAGGAAAAAGGGAAGTGCGGGTAGTGGAGATTTTGCTTGGTTACGAATTCTAAAGCA ATCATTTTTGTGTGGAGCATATTTCCTTACTCTTAATATAGGAGGGGCAGAGAAGGGAGCACTGGGGGAG CCAGCTAATGTCCAACAGAAGCAGCTTTGACGCAGGAAAAGGTTTATTTTGCTTT
• Restriction Sites: RsrII-NotI
• ACCN: NM_144843
• Insert Size: 1854 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC020019, AAH20019
• RefSeq Size: 3065 bp
• RefSeq ORF: 1854 bp
• Locus ID: 219135
• UniProt ID: Q8VE11
• Cytogenetics: 14 D1
• Gene Summary: Phosphatase that acts on lipids with a phosphoinositol headgroup. Dephosphorylates phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 3,5-bisphosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine (By similarity). Negatively regulates ER-Golgi protein transport (By similarity). Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles (PubMed:24591580). Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels (By similarity).[UniProtKB/Swiss-Prot Function]