Il23a (NM_031252) Mouse Untagged Clone

CAT#: MC201218

Il23a (untagged) - Mouse interleukin 23, alpha subunit p19 (Il23a), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Il23a
• Synonyms: IL-23; p19
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC019953 sequence for NM_031252
  TACAGAGTTAGACTCAGAACCAAAGGAGGTGGATAGGGGGTCCACAGGCCTGGTGCAGATCACAGAGCCA GCCAGATCTGAGAAGCAGGGAACAAGATGCTGGATTGCAGAGCAGTAATAATGCTATGGCTGTTGCCCTG GGTCACTCAGGGCCTGGCTGTGCCTAGGAGTAGCAGTCCTGACTGGGCTCAGTGCCAGCAGCTCTCTCGG AATCTCTGCATGCTAGCCTGGAACGCACATGCACCAGCGGGACATATGAATCTACTAAGAGAAGAAGAGG ATGAAGAGACTAAAAATAATGTGCCCCGTATCCAGTGTGAAGATGGTTGTGACCCACAAGGACTCAAGGA CAACAGCCAGTTCTGCTTGCAAAGGATCCGCCAAGGTCTGGCTTTTTATAAGCACCTGCTTGACTCTGAC ATCTTCAAAGGGGAGCCTGCTCTACTCCCTGATAGCCCCATGGAGCAACTTCACACCTCCCTACTAGGAC TCAGCCAACTCCTCCAGCCAGAGGATCACCCCCGGGAGACCCAACAGATGCCCAGCCTGAGTTCTAGTCA GCAGTGGCAGCGCCCCCTTCTCCGTTCCAAGATCCTTCGAAGCCTCCAGGCCTTTTTGGCCATAGCTGCC CGGGTCTTTGCCCACGGAGCAGCAACTCTGACTGAGCCCTTAGTGCCAACAGCTTAAGGATGCCCAGGTT CCCATGGCTACCATGATAAGACTAATCTATCAGCCCAGACATCTACCAGTTAATTAACCCATTAGGACTT GTGCTGTTCTTGTTTTGTTTGTTTTGCGTGAAGGGCAAGGACACCATTATTAAAGAGAAAAGAAACAAAC CCCAGAGCAGGCAGCTGGCTAGAGAAAGGAGCTGGAGAAGAAGAATAAAGTCTCGAGCCCTTGGCCTTGG AAGCGGGCAAGCAGCTGCGTGGCCTGAGGGGAAGGGGGCGGTGGCATCGAGAAACTGTGAGAAAACCCAG AGCATCAGAAAAAGTGAGCCCAGGCTTTGGCCATTATCTGTAAGAAAAACAAGAAAAGGGGAACATTATA CTTTCCTGGGTGGCTCAGGGAAATGTGCAGATGCACAGTACTCCAGACAGCAGCTCTGTACCTGCCTGCT CTGTCCCTCAGTTCTAACAGAATCTAGTCACTAAGAACTAACAGGACTACCAATACGAACTGACAAATAC TACCACTATGACCTGTGACAAAGCTGCATATTTATTAAGTGGGAAGGGAACTTTTGATATTATTTATCCT TGTAACAGTATAGATGATGGTTATTTATTCTATTTATAAGGAATTATGTATTTTTTTTTTCAATAAAGAT TTATTTATGTGGCTAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_031252
• Insert Size: 591 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC019953, AAH19953
• RefSeq Size: 1359 bp
• RefSeq ORF: 591 bp
• Locus ID: 83430
• UniProt ID: Q9EQ14
• Cytogenetics: 10 D3
• Gene Summary: Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.[UniProtKB/Swiss-Prot Function]