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Akr1b3 (BC004725) Mouse Untagged Clone

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SKU
MC200155
Akr1b3 (untagged) - Mouse aldo-keto reductase family 1, member B3 (aldose reductase) (cDNA clone MGC:5798 IMAGE:3582788), (10ug)
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  $300.00
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Specifications
Specifications
Product Data
Type Mouse Untagged Clone
Target Symbol Akr1b3
Synonyms Akr1b1, AR, ALR2
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
Fully Sequenced ORF
>BC004725
CGGACGCGTGGGTTTGTAACGTGCAGCGATCATGGCCAGCCATCTGGAACTCAACAACGGCACCAAGATG CCCACCCTGGGCCTGGGCACCTGGAAGTCCCCTCCTGGCCAGGTGACTGAGGCCGTGAAAGTTGCTATTG ACTTGGGGTACCGCCACATTGACTGCGCCCAGGTGTACCAGAATGAGAAGGAGGTGGGAGTGGCCCTCCA GGAGAAGCTCAAGGAGCAGGTGGTGAAGCGGCAGGATCTCTTCATTGTCAGCAAGCTGTGGTGCACGTTC CATGACAAGAGCATGGTGAAAGGAGCCTTCCAGAAGACACTGAGCGACCTGCAGCTGGACTACCTGGATC TCTACCTTATTCACTGGCCAACGGGGTTCAAGCCTGGGCCCGACTATTTCCCACTGGATGCCTCAGGGAA CGTGATACCTAGTGACACCGATTTTGTGGACACTTGGACGGCTATGGAACAACTAGTGGATGAAGGTTTG GTGAAAACAATCGGTGTCTCCAACTTCAACCCTCTTCAGATTGAGAGGATCTTGAACAAACCTGGCTTAA AATATAAGCCTGCGGTGAACCAGATCGAGTGCCACCCGTACCTAACTCAGGAGAAGCTGATTGAATACTG CCACAGCAAAGGCATCGTGGTGACAGCATATAGTCCCCTTGGTTCTCCTGACAGGCCCTGGGCCAAGCCT GAAGATCCGTCTCTCCTGGAGGATCCCAGGATCAAAGCAATTGCAGCCAAGTACAATAAAACTACAGCCC AGGTGCTGATCCGGTTCCCCATTCAGAGGAACTTGGTAGTGATCCCCAAGTCTGTGACACCAGTGCGCAT TGCTGAGAACTTGAAGGTCTTTGACTTTGAGCTGAGCAGCGAGGACATGGCCACTCTACTCAGCTACAAC AGGAACTGGAGGGTGTGCGCCTTGATGAGCTGTGCCAAACACAAGGATTACCCCTTCCACGCCGAAGTCT GAAGCTGTGGCGAGCGGATCCCTGCTCCTCCTCAAGTGGCTTGCACCTGTTCTTTCTGCCTCATCTGCCC TTGCAAGTGTCCTGTGTCTGCACTAGGTGGCACCTTGCAAACCAGATGGTGAGAGTTAGTTAGTTTGACA TAGAGTCTGGAGGGCAGTACCAGTAGCCAAGGTGTTTCTTCCAGCCTTCCTTGGTCTTTCTTCTTACCCA CCTGGAGGACTTTAACACAAGTACCCTTTCCAACCAAAGAGAAGCAAGCTTTAGAGTCCAAGCCGTGCCA CTAACACTTAAATGTGAGTGCTTAGAACTGTAATCCTTTGGGTCAGACTTCTCCTTGCCTCAAATAAAAA CTGCTTTTGTGAAAAAAAAAAAAAAAAA
Restriction Sites RsrII-NotI |
ACCN BC004725
Insert Size 951 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution Method 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq BC004725, AAH04725
RefSeq Size 1358 bp
RefSeq ORF 951 bp
Locus ID 11677
Cytogenetics 6 B1
Summary Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:17381426, PubMed:19010934, PubMed:7851421). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins (PubMed:19010934). Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (By similarity).UniProtKB/Swiss-Prot Function
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