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Cullin 2 (CUL2) (NM_003591) Human 3' UTR Clone

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SKU
SC206235
3' UTR clone of cullin 2 (CUL2) for miRNA target validation
  $683.00
4 Weeks*
Size
Bulk Requests & Clone Modifications

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Specifications
Specifications
Product Data
Vector pMirTarget
Species Human
Transfection Reporter RFP
Assay Reporter Luciferase
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Target Symbol Cullin 2
ACCN NM_003591
Insert Size 1790 bp
Sequence Data
Insert Sequence
>SC206235 3’UTR clone of NM_003591
The sequence shown below is from the reference sequence of NM_003591. The complete sequence of this clone may contain minor differences, such as SNPs.
Blue=Stop Codon Red=Cloning site

GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG
TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC
TCGGCAGATGAATACAGCTACGTCGCGTGATGTCGCTCTCCTCCAGCGTGGTGTGAGAAGATCATTGCC
ATCACCATTTGGTGTGTTCCTGTGGGAAAAAGCAGGACTGTGCCTCCATAATTTGGTCATTTGGCAGCC
CCTGTTTTCTGCTGTTTACAACATCACCAGTGCCACGTCATGAGCGTCAAAGAAAATGCCTAGAGATAT
TTCAAGCTCATGTCATTATGACATTTCTTAAAACTTTATTAAAAGAATGAGTGAAGTATTGCTGAAAAG
TGGAAATTCGGTTGGGTACCATGCTTTTTCTCCCCTTCACGTTTGCAGTTGATGTGTCTTTTTTTTTTT
TTTTAATGTATCTTAAAGGACATAAAATTTAAAAACTTAAATATTGTAATATGACAGATAACCTAATAA
TTGTATCTACATTAAAATGACAAACATGATACTGCTGCTTGTCAAATAAAAAAAAAATAAAGAAATAGA
ATGCCTTTTTTATGTGGATGGAGTATCAGGTTGACCACAAAATATATTGACTCAAAGCAGCTAATGCAT
CTTTAGTTGCGTTTTTATCTGAATGGTTTAATTCACTTGTACTCCTATTTAAATCCTACATGAAAAATG
TCTAGATTATTGTTCTTGACTGCATAGGACTGCATTCAGCATAAAGAATGCTTTATTTTTATGGATTAG
ATATATTGGATCTAAACATTTTGAATCTTGAAGATGTAATTCCATCAGCAGTTTCTGGTGGTGTGCTAC
TCCACAGACATCGCAGAGTGTGAGCAGGATGCTTGGTGACCTCAAGTCTGGCACAGAGAGAGCTTTTCA
TTCAAAAGTTGTCTTTCTTCGGTTGCATAATCCATTAATTCTAGCATAGACTAGTACCCTAGCTCTGTG
GCCTTCCCTGAGTCTTAGGAAATCTATGATACCAACATATTCCTTCTATATGCCTCCCCTACCTGTTAC
CCTTACAACCCTCCTCCAACAGTTTAGATACTAGAGTCACTCTCATCAATCACAGATGTGCTTAGCAAT
GCATAACCTAAATACTTTTTTAAAAAAGAAAATTGTACATTGTACTGGGTGCCACATATATAAATCCCA
TTATTTTGTTTATTTTATATATATATATATATATAATATATATATATATATATCTCAACAGCAGTGTTA
AGAGTACTGCGATCTATTATCATATTTATTGTCTATCCACACCATCACCACCACCACCACACCCCTCCT
CCCTCAACATACAATTTTTCTTTATTTTAAAAAAAATAAGAGACGGGGTTTCGCCATGTTTCCCAGGCT
AGTCTGGAACTTCTGGCCTCAAGCAATCCTATCTCTGTCTCCCAAAGTGCTGGGATTACAAGCATGAGC
CACTGCATCCATCCAACACAAAATTTTTAAAATCGGAATATTTTAAAGCAAATCACACAAATTATTTCA
CTTATAATACTTCAGTAAGGCCTTTAAAAAATCCACAGTGATATTATTACTCCTAACAAAAACAATAAT
TACTTAGTATCATCTAATATGTGGTTCATATTTAAATTTGTTGTTTTGAGATGGGTCTTACAATTGGTT
TATTCAATTGCATTTTTTCTAACTCGTGTCTCAAGTGTTTTAAAAATCTACTGAACTTATAATGACTTA
TATAATGTATTTCTCATTTTACCTTTCTTCCAAAAGAGGAAATAATGGCAAACCATATAATATTGTACA
TTCACTGTCAAAAAGCAAACCCTTGTTTTGATAACTTGTTGATTGATAAAAGTTTTCCAAATTGA
ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA
CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites SgfI-MluI |
OTI Disclaimer Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as 10 ug dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials.
Note Plasmids are not sterile.  For experiments where strict sterility is required, filtration with 0.22um filter is required.
Shipping Ambient
Reference Data
RefSeq NM_003591.4
Locus ID 8453
Summary Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).UniProtKB/Swiss-Prot Function
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.