Human Bestrophin 3 (BEST3) ELISA Kit 1 x 96

CAT#: EA200051

Human Bestrophin 3 (BEST3) ELISA Kit 1 x 96

Datasheet
SDS

Product Manual for 'EA200051'

USD 700.00

2 Weeks*

Size
    • 1 x 96 wells

Product Images

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Specifications

Product Data
Format 8x12 divisible strips
Assay Type Sandwich
Assay Length 3.5 hours incubations; 0.5 hour washing and analyzing samples
Signal Colorimetric
Curve Range 0.313-20ng/ml
Sample Type Human serum, plasma, cell lysates, tissue homogenates and other biological fluids.
Sample Volume 100µl
Specificity This kit is used for quantitative detection of BEST3
Sensitivity 197pg/ml
Reactivities Human
Cross Reactivity There is no detectable cross-reactivity with other relevant proteins.
Interference No significant interference observed with available related molecules.
Components
  • BEST3 MonoclonL Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate
  • Human BEST3 Standard (1µg/ml)|0.1 mL
  • 100x Biotin conjugated BEST3 Detection Antibody|0.12 mL
  • 100x SA-HRP Conjugate|0.12 mL
  • Assay Buffer|30 mL
  • Standard Diluent|10 mL
  • Sample Diluent|30 mL
  • Wash Buffer Concentrate 20X|60 mL
  • TMB Substrate|12 mL
  • Stop Solution|12 mL
  • Plate Sealer|3 pieces
Background Bestrophin 3 (BEST3) belongs to the bestrophin family of anion channels, which includes BEST1, BEST2 and BEST4. Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length. Bestrophin-3, essential for a calcium-activated chloride channel, recently was suggested to have cell-protective functions. BEST3 is an endogenous inhibitor of NF-κB signaling pathway in endothelial cells, and is involved in the regulation of cell proliferation, apoptosis and differentiation of a variety of physiological functions. Diseases associated with BEST3 include Vitelliform Macular Dystrophy and Viral Esophagitis. BEST-3 expression may be a novel approach for the treatment of vascular inflammatory diseases.
Gene Symbol BEST3
Gene ID 144453
Standard Curve
Data image of Human Bestrophin 3 (BEST3) ELISA Kit.

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