MSH6 Mouse Monoclonal Antibody [Clone ID: UMAB258]

USD 180.00


Availability*
In Stock

Size
    • 30 ul


Specifications

Product Data
Clone Name UMAB258
Applications IHC
Recommend Dilution IHC 1:50
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 1-280 of human MSH6(NP_000170) produced in E.coli.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from cell culture supernatant by affinity chromatography
Gene Name Homo sapiens mutS homolog 6 (MSH6), transcript variant 1
Background This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
Synonyms GTBP; GTMBP; HNPCC5; HSAP; p160
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Colorectal cancer, Mismatch repair, Pathways in cancer

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