E Cadherin (CDH1) Mouse Monoclonal Antibody [Clone ID: UMAB184]

USD 468.00


Availability*
In Stock

Size
    • 100 ul


Specifications

Product Data
Clone Name UMAB184
Applications 10k-ChIP, FC, IF, IHC, WB
Recommend Dilution IHC 1:100~200
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen The extracellular domain of human CDH1 (NP_004351) produced in human cells.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from cell culture supernatant by affinity chromatography
Predicted Protein Size 94.8 kDa
Gene Name Homo sapiens cadherin 1 (CDH1), transcript variant 1
Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008]
Synonyms Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer

Citations (1)

Other Versions

Other products for "CDH1"
Frequently bought together (2)
Transient overexpression lysate of cadherin 1, type 1, E-cadherin (epithelial) (CDH1)
    • 100 ug

USD 495.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 150.00

Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
68 Mouse Clones