ErbB 2(ERBB2) Mouse Monoclonal Antibody [Clone ID: UMAB36]

CAT#: UM500036

Purified HER2 (ERBB2) mouse monoclonal antibody,clone UMAB36

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 Product Datasheet for 'UM500036'

USD 468.00


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name UMAB36
Applications WB, IHC, IF, 10K-CHIP
Recommend Dilution WB:1:500, IHC:1:50, IF:1:100
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 676-1255 of human ERBB2(NP_004439) produced in HEK293T cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 137.7 kDa
Gene Name Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 1
Background This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].
Synonyms CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
Reference Data
Protein Families Protein Kinase, Transmembrane, Druggable Genome
Protein Pathways ErbB signaling pathway, Calcium signaling pathway, Focal adhesion, Adherens junction, Pathways in cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations