SHP2 (PTPN11) Rabbit Polyclonal Antibody

CAT#: TA890142

Rabbit Polyclonal anti-PTPN11 Antibody

Size: 30 ul 100 ul


 

USD 407.00

In Stock*

Size
    • 100 ul

Product Images

Frequently bought together (2)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

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Recombinant protein of human protein tyrosine phosphatase, non-receptor type 11 (PTPN11), 20 µg
    • 20 ug

USD 867.00

Other products for "PTPN11"

Specifications

Product Data
Applications WB
Recommended Dilution WB: 1:500~2000
Reactivities Human, Rat, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen Recombinant protein of human PTPN11
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration 2.23 mg/ml
Purification Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 67.8 kDa
Gene Name protein tyrosine phosphatase, non-receptor type 11
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
Synonyms BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma

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