alpha 1 Fetoprotein (AFP) Mouse Monoclonal Antibody [Clone ID: OTI2F11]
AFP mouse monoclonal antibody, clone OTI2F11 (formerly 2F11)
Product Datasheet for 'TA809081'
|Applications||IF, IHC, WB|
|Recommend Dilution||WB 1:2000, IHC 1:150, IF 1:100|
|Immunogen||Human recombinant protein fragment corresponding to amino acids 19-397 of human AFP (NP_001125) produced in E.coli.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||66.3 kDa|
|Gene Name||alpha fetoprotein|
|Background||This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]|
|Synonyms||AFPD; FETA; HPAFP|
|Protein Families||Druggable Genome, Secreted Protein|
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