MSH6 Mouse Monoclonal Antibody [Clone ID: OTI5D1]
MSH6 mouse monoclonal antibody,clone OTI5D1
Product Datasheet for 'TA807929'
|Recommend Dilution||WB 1:2000, IHC 1:150|
|Immunogen||Human recombinant protein fragment corresponding to amino acids 1-280 of human MSH6(NP_000170) produced in E.coli.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Gene Name||mutS homolog 6|
|Background||This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]|
|Synonyms||GTBP; GTMBP; HNPCC5; HSAP; p160|
|Protein Families||Druggable Genome, Stem cell - Pluripotency|
|Protein Pathways||Colorectal cancer, Mismatch repair, Pathways in cancer|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.