IL12B Mouse Monoclonal Antibody [Clone ID: OTI1A3]

CAT#: TA807426

IL12B mouse monoclonal antibody, clone OTI1A3 (formerly 1A3)


 Product Datasheet for 'TA807426'

  View other "OTI1A3" antibodies (1)

USD 360.00


Availability*
In Stock

Size
    • 100 ul


Product images

Specifications

Product Data
Clone Name OTI1A3
Applications WB
Recommend Dilution WB 1:2000,
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human IL12B (NP_002178) produced in SF9 cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1.00mg/ml
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 34.6 kDa
Gene Name interleukin 12B
Background This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
Synonyms CLMF|CLMF2|IL-12B|IMD28|IMD29|NKSF|NKSF2
Reference Data
Protein Families Secreted Protein, Transmembrane, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Jak-STAT signaling pathway, Type I diabetes mellitus, Allograft rejection

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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