IL12B Mouse Monoclonal Antibody [Clone ID: OTI1A3]
IL12B mouse monoclonal antibody, clone OTI1A3 (formerly 1A3)
Product Datasheet for 'TA807426'
Use code "SUMMER" to get 40% off list price.
|Recommend Dilution||WB 1:2000|
|Immunogen||Full length human recombinant protein of human IL12B (NP_002178) produced in SF9 cell.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Predicted Protein Size||34.6 kDa|
|Gene Name||interleukin 12B|
|Background||This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]|
|Synonyms||CLMF; CLMF2; IL-12B; IMD28; IMD29; NKSF; NKSF2|
|Protein Families||Druggable Genome, Secreted Protein, Transmembrane|
|Protein Pathways||Allograft rejection, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus|