Apolipoprotein E (APOE) Mouse Monoclonal Antibody [Clone ID: OTI2A4]

CAT#: TA805331S

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APOE mouse monoclonal antibody, clone OTI2A4 (formerly 2A4)


Product Datasheet for 'TA805331S'


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USD 159.00


Availability*
2 Days

Size
    • 30 ul


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Specifications

Product Data
Clone Name OTI2A4
Applications IHC, WB
Recommended Dilution WB 1:500, IHC 1:150
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human APOE (NP_000032) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 34.2 kDa
Gene Name apolipoprotein E
Background Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]
Synonyms AD2; APO-E; LDLCQ5; LPG
Reference Data
Protein Families Adult stem cells, Druggable Genome, Secreted Protein, Stem cell - Pluripotency
Protein Pathways Alzheimer's disease

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