Isocitrate dehydrogenase(IDH1) Mouse Monoclonal Antibody [Clone ID: OTI24A2]
IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI24A2 (formerly 24A2)
Product Datasheet for 'TA800426'
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|Recommend Dilution||WB 1:2000, IHC 1:150,|
|Reactivity||Human , Dog , Rat , Monkey , Mouse|
|Immunogen||Synthetic peptide around the R132 region of the human IDH conjugated to KLH|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from mouse ascites fluids by affinity chromatography|
|Predicted Protein Size||46.5 kDa|
|Gene Name||isocitrate dehydrogenase (NADP(+)) 1, cytosolic|
|Background||Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].|
|Protein Pathways||Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways|