Isocitrate dehydrogenase(IDH1) Mouse Monoclonal Antibody [Clone ID: OTI24A2]

CAT#: TA800426

IDH1 (Isocitrate Dehydrogenase 1) mouse monoclonal antibody, clone OTI24A2 (formerly 24A2)

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 Product Datasheet for 'TA800426'

USD 379.00


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name OTI24A2
Applications WB, IHC
Recommend Dilution WB 1:2000, IHC 1:150,
Reactivity Human , Dog , Rat , Monkey , Mouse
Host Mouse
Clonality Monoclonal
Immunogen Synthetic peptide around the R132 region of the human IDH conjugated to KLH
Isotype IgG2b
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 46.5 kDa
Gene Name isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Background Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].
Synonyms HEL-216|HEL-S-26|IDCD|IDH|IDP|IDPC|PICD
Reference Data
Protein Pathways Citrate cycle (TCA cycle), Glutathione metabolism, Metabolic pathways
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