ANK1 Rabbit Monoclonal Antibody [Clone ID: OTIR3A12]

CAT#: TA591034

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Rabbit monoclonal anti-ANK1 antibody for SISCAPA, clone OTIR3A12


Product Datasheet for 'TA591034'


USD 428.00


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Size
    • 100 ul


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Specifications

Product Data
Clone Name OTIR3A12
Applications SISCAPA
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen Synthetic peptide LALQAQPVPDELVTK
Formulation Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
Concentration Lot dependent; please refer to CoA along with shipment
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 206.3 kDa
Gene Name ankyrin 1
Background Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin 1 resulting from usage of an alternate promoter have also been identified. [provided by RefSeq, Dec 2008]
Synonyms ANK; ankyrin-R; SPH1; SPH2
Reference Data
Protein Families Transmembrane
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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