PIG3(TP53I3) Rabbit Polyclonal Antibody
Rabbit Polyclonal PIG3 Antibody
Product Datasheet for 'TA590395'
|Applications||WB, ELISA, IHC|
|Recommend Dilution||WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000|
|Reactivity||Human , Monkey|
|Immunogen||DNA immunization. This antibody is specific for the N Terminus Region of the target protein.|
|Formulation||20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0|
|Purification||The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.|
|Gene Name||tumor protein p53 inducible protein 3|
|Background||The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. At least two transcript variants encoding the same protein have been found for this gene.|
|Note||This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT|
|Protein Families||Druggable Genome|
|Protein Pathways||p53 signaling pathway|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.