EGFR Rabbit Polyclonal Antibody

CAT#: TA590341

Rabbit Polyclonal EGFR Antibody

Antibody Service


 Product Datasheet for 'TA590341'

USD 409


Availability*
In Stock

Size
    • 100 ug

Product images

Specifications

Product Data
Clone Name Polyclonal
Applications ELISA
Recommend Dilution WB: 1:5000-1:20000; ELISA: 1:100-1:2000
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen DNA immunization. This antibody is specific for the C Terminus Region of the target protein.
Isotype IgG
Formulation 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Concentration 1.05474 mg/ml
Purification The fragment used for DNA immunization was expressed in E.coli and the purified protein fragment was used for affinity purification of the antibody.
Gene Name epidermal growth factor receptor
Background Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR over expression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
Synonyms ERBB|ERBB1|HER1|NISBD2|PIG61|mENA
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
Reference Data
Protein Families Stem cell relevant signaling - JAK/STAT signaling pathway, Protein Kinase, Secreted Protein, ES Cell Differentiation/IPS, Transmembrane, Adult stem cells, Cancer stem cells, Druggable Genome
Protein Pathways MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Dorso-ventral axis formation, Focal adhesion, Adherens junction, Gap junction, Regulation of actin cytoskeleton, GnRH signaling pathway, Epithelial cell signaling in Helicobacter pylori infection, Pathways in cancer, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.