KEAP1 Rabbit Polyclonal Antibody

CAT#: TA590238

Rabbit Polyclonal KEAP1 Antibody


USD 482.00

In Stock*

Size
    • 100 ug

Frequently bought together (3)
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Specifications

Product Data
Applications ELISA, IHC, WB
Recommended Dilution WB 1:5000~20000, IHC 1:150,ELISA 1:100-1:2000
Reactivities Human
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen DNA immunization. This antibody is specific for the N Terminus Region of the target protein.
Formulation 20 mM Potassium Phosphate, 150 mM Sodium Chloride, pH 7.0
Concentration 0.9mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name kelch like ECH associated protein 1
Background KEAP1 retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Synonyms INrf2; KLHL19
Note This antibody was generated by SDIX's Genomic Antibody Technology ® (GAT). Learn about GAT
Reference Data
Protein Families Transcription Factors
Protein Pathways Ubiquitin mediated proteolysis

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