TGF beta 1 (TGFB1) Mouse Monoclonal Antibody [Clone ID: OTI1E12]

CAT#: TA506585

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TGFB1 mouse monoclonal antibody, clone OTI1E12 (formerly 1E12)


Product Datasheet for 'TA506585'


  View other "OTI1E12" antibodies (2)

USD 379.00


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Specifications

Product Data
Clone Name OTI1E12
Applications FC, IF, WB
Recommended Dilution WB 1:1000, IF 1:100, FLOW 1:50
Reactivity Human
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Full length human recombinant protein of human TGFB1(NP_000651) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Predicted Protein Size 28.4 kDa
Gene Name transforming growth factor beta 1
Background This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Oct
Synonyms CED; DPD1; LAP; TGFB; TGFbeta
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Transcription Factors
Protein Pathways Cell cycle, Chronic myeloid leukemia, Colorectal cancer, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, TGF-beta signaling pathway

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