ERG Mouse Monoclonal Antibody [Clone ID: OTI6A4]

CAT#: TA506078

ERG mouse monoclonal antibody,clone OTI6A4

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 Product Datasheet for 'TA506078'

USD 350.00


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Size
    • 100 ul

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Specifications

Product Data
Clone Name OTI6A4
Applications WB, IHC, IF
Recommend Dilution WB 1:4000, IHC 1:150, IF 1:100,
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human ERG(NP_891548) produced in HEK293T cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Reconstitution Method Reconstitute with PBS (pH7.3). To use this carrier-free antibody for conjugation experiment, we strongly recommend you to perform another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific)
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 53.7 kDa
Gene Name ERG, ETS transcription factor
Background This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan
Synonyms erg-3|p55
Reference Data
Protein Families Transcription Factors, Druggable Genome
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