SHP2 (PTPN11) Mouse Monoclonal Antibody [Clone ID: OTI1F7]

CAT#: TA501914

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PTPN11 (SHP2) mouse monoclonal antibody, clone OTI1F7 (formerly 1F7)



  View other "OTI1F7" antibodies (2)

USD 379.00


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In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name OTI1F7
Applications FC, WB
Recommended Dilution WB 1:1000, FLOW 1:100
Reactivity Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human PTPN11(NP_002825) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.86 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 67.8 kDa
Gene Name protein tyrosine phosphatase non-receptor type 11
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq]
Synonyms BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; SH-PTP2; SH-PTP3; SHP2
Reference Data
Protein Families Druggable Genome, Phosphatase
Protein Pathways Adipocytokine signaling pathway, Chronic myeloid leukemia, Epithelial cell signaling in Helicobacter pylori infection, Jak-STAT signaling pathway, Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Renal cell carcinoma

Other Versions

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