B Raf (BRAF) Mouse Monoclonal Antibody [Clone ID: OTI1E2]
Anti-BRAF mouse monoclonal antibody, clone OTI1E2 (formerly 1E2)
Product Datasheet for 'TA500845'
|Applications||FC, IF, IP, WB|
|Recommend Dilution||WB 1:2000, IF 1:100, Flow 1:100|
|Immunogen||Full length human recombinant protein of human BRAF (NP_004324) produced in HEK293T cell.|
|Formulation||PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||84.4 kDa|
|Gene Name||B-Raf proto-oncogene, serine/threonine kinase|
|Background||This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene.|
|Synonyms||B-raf; B-RAF1; BRAF1; NS7; RAFB1|
|Protein Families||Druggable Genome, Protein Kinase|
|Protein Pathways||Acute myeloid leukemia, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Focal adhesion, Glioma, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, Thyroid cancer, Vascular smooth muscle contraction|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.