PTCH1(PTCH1) Mouse Monoclonal Antibody [Clone ID: OTI5C7]

CAT#: TA500123

Patched1 (Patched) mouse monoclonal antibody, clone OTI5C7 (formerly 5C7)

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 Product Datasheet for 'TA500123'

USD 379


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name OTI5C7
Applications WB, IHC, IF
Recommend Dilution WB 1:500, IHC 1:50, IF 1:100,
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 122-436 of human PTCH1 (NP_000255) produced in E.coli.
Isotype IgG2b
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.2 mg/ml
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 160.4 kDa
Gene Name patched 1
Background This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.
Synonyms BCNS|HPE7|NBCCS|PTC|PTC1|PTCH|PTCH11
Reference Data
Protein Families ES Cell Differentiation/IPS, Transmembrane, Druggable Genome
Protein Pathways Hedgehog signaling pathway, Pathways in cancer, Basal cell carcinoma
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations