NOTCH1 Mouse Monoclonal Antibody [Clone ID: OTI3E12]

CAT#: TA500078

Reviews ()
Write a review

Anti-Notch1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12)


Product Datasheet for 'TA500078'


 Cited in 2 publications.

  View other "OTI3E12" antibodies (2)

USD 379.00


Availability*
In Stock

Size
    • 100 ul


Specifications

Product Data
Clone Name OTI3E12
Applications IF, IHC, WB
Recommended Dilution WB: 1:1000; IHC 1;50; RPPA 1:75; IF: 1:100
Reactivity Human
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.2 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 270.6 kDa
Gene Name notch 1
Background Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development
Synonyms AOS5; AOVD1; hN1; TAN1
Reference Data
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway
Protein Pathways Dorso-ventral axis formation, Notch signaling pathway, Prion diseases

Citations (2)

Other Versions

Other products for "NOTCH1"
Frequently bought together (2)
Transient overexpression lysate of Notch homolog 1, translocation-associated (Drosophila) (NOTCH1)
    • 100 ug

USD 495.00


beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

USD 159.00

Customer Reviews 
Loading...
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
Antibody Performance Guarantee banner
ANTIBODY VALIDATION 101
Clone ID reveals the Source of Monoclonal Antibodies