Notch1 Mouse Monoclonal Antibody [Clone ID: OTI3E12]

CAT#: TA500078

anti-Notch1 mouse monoclonal antibody, clone OTI3E12 (formerly 3E12)

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 Product Datasheet for 'TA500078'

USD 379

In Stock

    • 100 ul


Product Data
Clone Name OTI3E12
Applications WB, IHC, IF
Recommend Dilution WB: 1:1000; IHC 1;50; RPPA 1:75; IF: 1:100
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Recombinant protein expressed in E.coli corresponding to amino acids 2300-2556 of human NOTCH1
Isotype IgG2b
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.2 mg/ml
Purification Puridied form mouse ascites fluids
Predicted Protein Size 270.6 kDa
Gene Name notch 1
Background Notch1 is a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development
Synonyms AOS5|AOVD1|TAN1|hN1
Reference Data
Protein Families Stem cell relevant signaling - DSL/Notch pathway, ES Cell Differentiation/IPS, Adult stem cells, Cancer stem cells, Druggable Genome
Protein Pathways Dorso-ventral axis formation, Notch signaling pathway, Prion diseases
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