alpha Actinin(ACTN1) Mouse Monoclonal Antibody [Clone ID: OTI7A4]

CAT#: TA500072

alpha-actinin (Actinin alpha 1) mouse monoclonal antibody, clone OTI7A4 (formerly 7A4)

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 Product Datasheet for 'TA500072'

USD 379


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name OTI7A4
Applications WB, IHC, IF
Recommend Dilution WB 1:2000, IHC 1:50, IF 1:100,
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 650-893 of human alpha-actinin (NP_001093) produced in E.coli.
Isotype IgG2a
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1.00mg/ml
Purification Purified from cell culture supernatant by affinity chromatography
Predicted Protein Size 102.9 kDa
Gene Name actinin alpha 1
Background Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Synonyms BDPLT15
Reference Data
Protein Families ES Cell Differentiation/IPS, Druggable Genome
Protein Pathways Focal adhesion, Adherens junction, Tight junction, Leukocyte transendothelial migration, Regulation of actin cytoskeleton, Systemic lupus erythematosus, Arrhythmogenic right ventricular cardiomyopathy (ARVC)
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations