p16INK4A (CDKN2A) Mouse Monoclonal Antibody [Clone ID: OTI4C11]
$200.00
2 Days*
Specifications
| Product Data | |
| Clone Name | OTI4C11 |
|---|---|
| Application | IF, IHC, WB |
| Recommended Dilution | WB 1:1000, IF 1:100, IHC 1:150 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 16.4 kDa |
| Gene Name | cyclin dependent kinase inhibitor 2A |
| Database Link | |
| Background | P16 gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
| Synonyms | ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI4C11" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF500036 | Carrier-free (BSA/glycerol-free) P16 mouse monoclonal antibody, clone OTI4C11 (formerly 4C11) | 100 ug |
$620.00
|
|
| TA500036 | Anti-CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI4C11 (formerly 4C11) | 100 ul |
$447.00
|
|
| TA500036AM | P16 mouse monoclonal antibody, clone 4C11, Biotinylated | 100 ul |
$509.00
|
|
| TA500036BM | P16 mouse monoclonal antibody, clone 4C11, HRP conjugated | 100 ul |
$509.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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