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p16INK4A (CDKN2A) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4C11]

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SKU
TA500036AM
P16 mouse monoclonal antibody, clone 4C11, Biotinylated
Size:
100 ul
Conjugation:
Biotin Unconjugated HRP
  $509.00
5 Days*
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View other "p16INK4A or NM_000077" antibodies

Specifications
Specifications
Product Data
Clone Name OTI4C11
Application IF, IHC, WB
Recommended Dilution WB 1:1000, IF 1:100, IHC 1:150
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Biotin
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 16.4 kDa
Gene Name cyclin dependent kinase inhibitor 2A
Database Link
Background P16 gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Synonyms ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4
Reference Data
Protein Families Druggable Genome
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer
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Other "OTI4C11" antibodies (4)
SKU Description Size Price
CF500036 Carrier-free (BSA/glycerol-free) P16 mouse monoclonal antibody, clone OTI4C11 (formerly 4C11) 100 ug
$620.00
TA500036 Anti-CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI4C11 (formerly 4C11) 100 ul
$447.00
TA500036BM P16 mouse monoclonal antibody, clone 4C11, HRP conjugated 100 ul
$509.00
TA500036S Anti-CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI4C11 (formerly 4C11) 30 ul
$200.00

file-alt Citations

Miniaturized Drug Discovery Assays Targeting Macrophages in Fibrotic Diseases
Groetzner
Thesis (2024)
Snippet: Anti-α-Tubulin, Alexa Fluor 488 conjugated 53-4502-82 Invitrogen 1:100 CD47 MA5-11895 Invitrogen 1:100 p16 CF500036 OriGene 1:100 p21 MA5-14949 Invitrogen 1:100 Anti-Mouse IgG, Alexa Fluor 488 conjugated A-11029 Invitrogen 1:1000 Anti-Rabbit IgG, Alexa Fluor 546 conjugated A-11010 Invitrogen 1:1000
IF
Silencing p53 inhibits interleukin 10-induced activated hepatic stellate cell senescence and fibrotic degradation in vivo
Guo, Chen, Chen et al
Exp Biol Med (Maywood) (2020)
Cited by 19
AI Summary: OriGene’s P16 antibody was used to assess senescence-related protein expression in hepatic stellate cells, helping to elucidate the role of p53 in IL-10-induced anti-fibrotic effects in this study.
Snippet: Ltd, China);fluorescent anti-quenching agent (Invitrogen, United States);Hyaluronic Acid Detection Kit (Zhengzhou Autobio Engineering Co., Ltd, China). Antibodies were used in these experiments: HMGA1, P53, P27 (Cell Signaling Technology Company, United States);P21 (109199) and α-smooth muscle actin (α-SMA) (ab32575) (Abcam Company, Hong Kong, China);β-actin (Sigma, United States), P16 (OriGene, C...
M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB‑EGF
Fu, Liu, Yu et al
Oncol Rep (2020) 44 (2), 698-710 DOI: 10.3892/or.2020.7628
Cited by 39
AI Summary: In this study, OriGene’s HB-EGF overexpression plasmid (HG10082-UT) and HB-EGF shRNA plasmid (TG311253) were used to manipulate HB-EGF expression in HNSCC cells, enabling the authors to demonstrate that HB-EGF secreted by M2 macrophages reduces the radiosensitivity of head and neck cancer cells.
FigureFigureFigure
M2 macrophages reduce the radiosensitivity of head and neck cancer by releasing HB‑EGF
Fu, Liu, Yu et al
Oncol Rep (2020)
Cited by 39
AI Summary: In this study, OriGene products p16 (cat. no. TA500036) and CD163 (cat. no. TA130015) antibodies were used to assess protein expression related to macrophage activity and radiosensitivity in head and neck cancer tissues.
Snippet: The expression of p16 (cat. no. TA500036;OriGene Technologies, Inc.), inducible nitric oxide synthase (iNOS;1:100;product code ab53769;Abcam), CD163 (1:100;cat. no no. TA130015;OriGene Technologies, Inc.) for 60 min at room temperature;- The expression of p16 (cat. no. TA500036
Predictive value of p16INK4a, Ki-67 and ProExC immuno-qualitative features in LSIL progression into HSIL
Ding, Song, Zhao et al
Exp Ther Med (2020) 19 (4), 2457-2466 DOI: 10.3892/etm.2020.8496
Cited by 17
AI Summary: In this study, OriGene's ProExC immunohistochemical cocktail was used to assess protein expression in LSIL patient biopsies, contributing to the finding that ProExC expression is an independent risk factor for LSIL progression into HSIL.
FigureFigureFigure
Predictive value of p16INK4a, Ki‑67 and ProExC immuno‑qualitative features in LSIL progression into HSIL
Ding, Song, Zhao et al
Exp Ther Med (2020) 19 (4), 2457-2466 DOI: 10.3892/etm.2020.8496
Cited by 17
AI Summary: In this study, OriGene products—including normal goat serum (used for blocking, ZSGB‑BIO; OriGene Technologies, Inc.) and monoclonal mouse anti‑Ki‑67 antibody (cat. no. TA500036; OriGene Technologies, Inc.)—were utilized in the immunohistochemical analysis to assess the expression of key biomarkers predicting the progression of LSIL to HSIL.
Snippet: The sections were blocked with 10% normal goat serum (ZSGB‑BIO;OriGene Technologies, Inc.) for 10 min at room temperature followed Page 3 no. TA500036;OriGene Technologies, Inc.), monoclonal mouse anti‑Ki‑67 (1:100;cat. no
IHC
Showing 1-6 of 14 papers.
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