p16INK4A(CDKN2A) Mouse Monoclonal Antibody [Clone ID: OTI4C11]

CAT#: TA500036

anti-CDKN2A (p16INK4a) mouse monoclonal antibody, clone OTI4C11 (formerly 4C11)

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 Product Datasheet for 'TA500036'

USD 379


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name OTI4C11
Applications WB, IHC, IF
Recommend Dilution WB 1:1000, IF 1:100, IHC 1:150
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human CDKN2A (NP_000068) produced in E.coli.
Isotype IgG1
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 16.4 kDa
Gene Name cyclin-dependent kinase inhibitor 2A
Background P16 gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
Synonyms ARF|CDK4I|CDKN2|CMM2|INK4|INK4A|MLM|MTS-1|MTS1|P14|P14ARF|P16|P16-INK4A|P16INK4|P16INK4A|P19|P19ARF|TP16
Reference Data
Protein Families Druggable Genome
Protein Pathways Cell cycle, p53 signaling pathway, Pathways in cancer, Pancreatic cancer, Glioma, Melanoma, Bladder cancer, Chronic myeloid leukemia, Non-small cell lung cancer
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Citations