PGC1 alpha (PPARGC1A) Rabbit Polyclonal Antibody

SKU TA392487

PRGC1 (T56) polyclonal antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1:1000~1:2000
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide, corresponding to Human PRGC1.
• Specificity: PRGC1 (T56) polyclonal antibody detects endogenous levels of PRGC1 protein.
• Buffer: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
• Concentration: 1mg/ml
• Conjugation: Unconjugated
• Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
• Stability: 1 year
• Shipping: Blue Ice
• Predicted Protein Size: ~ 95 kDa
• Gene Name: PPARG coactivator 1 alpha
• Database Link:
  Q9UBK2
• Background: PPARγ coactivator-1α (PGC-1α) was originally identified as a transcriptional coactivator whose expression closely correlated with adaptive thermogenesis following exposure to cold temperatures. Named for its association with the nuclear receptor peroxisome-proliferator activated receptor (PPARγ), PGC-1α interacts with a diverse array of transcription factors to regulate numerous aspects of cell physiology. PGC-1α helps to regulate cell processes important in adaptive thermogenesis and energy metabolism, including the related functions of glucose uptake, gluconeogenesis, insulin secretion, and mitochondrial biogenesis. Long thought to be a potential therapeutic target for the treatment of type II diabetes, obesity, cardiomyopathy, or other metabolic disorders (reviewed in 4), a recent functional survey found no obvious differences in PPARγ activity associated with recognized PGC-1α variants.
• Synonyms: LEM6; Ligand effect modulator 6; Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; PGC1; PGC1A; PPAR-gamma coactivator 1-alpha; PPARGC-1-alpha; PPARGC1; PPARGC1A
• Note: For research use only, not for use in diagnostic procedure.

Reference Data