PML Protein (PML) Rabbit Polyclonal Antibody

CAT#: TA380079

PML(isoform 5) Rabbit polyclonal Antibody


USD 313.00

3 Weeks*

Size
    • 100 ul

Product Images

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    • 30 ul

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Specifications

Product Data
Applications ICC/IF, WB
Recommended Dilution WB,1:500 - 1:2000
IF,1:50 - 1:200
Reactivities Mouse, Rat, Human
Modifications Unmodified
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen A synthetic peptide of human PML.
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Store at -20℃. Avoid freeze / thaw cycles.
Stability Shelf life: one year from despatch.
Predicted Protein Size 47-48kDa/62-97kDa
Gene Name promyelocytic leukemia
Background The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.
Synonyms MYL; PP8675; RNF71; TRIM19
Reference Data

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.