GSDMA Rabbit Polyclonal Antibody

CAT#: TA366635S

GSDMA rabbit polyclonal antibody

Product Images

Gel: 8%SDS-PAGE Lysate: 40 μg Lane 1-2: LO2 and 293T cell lysates Primary antibody: TA366635 (GSDMA Antibody) at dilution 1/800 Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution Exposure time: 5 minutes

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  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA366635 (GSDMA Antibody) at dilution 1/115 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using TA366635 (GSDMA Antibody) at dilution 1/115, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA366635 (GSDMA Antibody) at dilution 1/115 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using TA366635 (GSDMA Antibody) at dilution 1/115, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 500-2000
  WB positive control: LO2 and 293T cell lysates
  IHC: 100-200
  Positive control: Human colorectal cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein of human GSDMA
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glycerol
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C.
• Stability: 1 year
• Predicted Protein Size: 49 kDa
• Gene Name: gasdermin A
• Database Link:
  Entrez Gene 284110 Human
  UniProt ID Q96QA5
• Background: May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
• Synonyms: FKSG9; FLJ39120; gasdermin; Gasdermin-1; GSDM; GSDM1; MGC129596