Phospholamban (PLN) Rabbit Polyclonal Antibody

CAT#: TA355106

Rabbit Polyclonal anti-Phospho-PLB(T17) Antibody

Product Images

Dot blot analysis of anti-Phospho-PLB-T17 Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Specifications

Product Data

• Applications: Dot
• Recommended Dilution: DB 1:500
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The PLB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T17 of human PLB.
• Formulation: PBS with 0.09% (W/V) sodium azide
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 6.1 kDa
• Gene Name: phospholamban
• Database Link:
  NP_002658
  Entrez Gene 5350 Human
  UniProt ID P26678
• Background: Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases; whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.
• Synonyms: CMD1P; phospholamban; PLB

Reference Data

• Protein Families: Transmembrane
• Protein Pathways: Calcium signaling pathway, Dilated cardiomyopathy