PD L2 (PDCD1LG2) Mouse Monoclonal Antibody [Clone ID: 10H6]

CAT#: TA355065

Mouse Monoclonal Anti-PD-L2 Antibody [10H6]

Product Images

Western blot analysis of PD-L2 in overexpressing HEK293 cells PD-L2 antibody at 0.5 and 1ug/ml

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  Immunohistochemistry of PD-L2 in human tonsil tissue with PD-L2 antibody at 2ug/ml.

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  Immunohistochemistry of PD-L2 in human colon carcinoma tissue with PD-L2 antibody at 2ug/ml.

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  Immunofluorescence of PD-L2 in transfected HEK293 cells with PD-L2 antibody at 20ug/ml.

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  Immunofluorescence of PD-L2 in human tonsil tissue with PD-L2 antibody at 20ug/ml.

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  Immunofluorescence of PD-L2 in human colon carcinoma tissue with PD-L2 antibody at 20ug/ml.

• Immunocytochemistry of PD-L2 in transfected HEK293 cells with PD-L2 antibody at 5ug/ml. Lower left: Immunocytochemistry in transfected HEK293 cells with control mouse IgG antibody at 5ug/ml.

• Flow cytometry analysis of PD-L2 overexpressing HEK293 cells using PD-L2 antibody and control mouse IgG antibody at 10ug/ml. Blue: Untransfected HEK293 cells. Yellow: PD-L2 overexpressing HEK293 cells.

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Specifications

Product Data

• Clone Name: 10H6
• Applications: FC, IF, IHC, WB
• Recommended Dilution: WB: 0.5-1µg/mL.IHC starting at 2µg/mL.IF start at 20µg/mL.
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: PD-L2 antibody was raised against the extracellular domain of human PD-L2.
• Formulation: PD-L2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Concentration: 1 mg/ml
• Purification: PD-L2 Antibody is supplied as protein A purified IgG1.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: Predicted: 30 kDa; Observed: 38 kDa
• Gene Name: programmed cell death 1 ligand 2
• Database Link:
  NP_079515
  Entrez Gene 80380 Human
  UniProt ID Q9BQ51
• Background: PD-L2 Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by co gnate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PD-L1 and PD-L2, both of which are thought act as a negative regulator of T cell activation. However, it has been suggested that PD-L2 can act to stimulate an immunogenic response through and alternative receptor from PD-1.
• Synonyms: B7-DC; B7DC; bA574F11.2; Btdc; CD273; MGC142238; MGC142240; PD-L2; PDCD1L2; PDL2
• Note: PD-L2 antibody can be used for detection of PD-L2 by Western blot at 0.5 - 1 µg/mL. Antibody can also be used for immunohistochemistry starting at 2 µg/mL. For immunofluorescence start at 20 µg/mL.