AKT1 Rabbit Polyclonal Antibody
Rabbit anti AKT1 (paried T308) Polyclonal Antibody
Product Datasheet for 'TA354873'
|Recommend Dilution||WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml|
|Reactivity||Human, Mouse, Rat|
|Immunogen||A synthetic peptide containing the motif (GATMKTFCG) without phosphorylation at Thr308 of human AKT1.|
|Formulation||This affinity purified antibody is supplied in sterile Tris-buffered saline (pH7.2) containing antibody stabilizer.|
|Purification||The Rabbit IgG is purified by Epitope Affinity Purification|
|Gene Name||AKT serine/threonine kinase 1|
|Background||Akt also known as PKB (Protein kinase B) is a family of serine/threonine kinases that plays an important role in signal transduction. There are three known isoforms of Akt in mammalian cells [Akt1 (a), Akt2 (β) and Akt3 (?)]; Akt is activated by insulin and growth and survival factors. Akt1 is phosphorylated at Thr308 and Ser473. Additionally, Akt has been referred to as an oncogene because it has increased activity in a number of tumors.|
|Synonyms||AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase|
|Protein Pathways||Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Tight junction, Toll-like receptor signaling pathway, VEGF signaling pathway|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.