ATP2A1 Rabbit Polyclonal Antibody

CAT#: TA351399

Rabbit Polyclonal Anti-ATP2A1 Antibody

Product Images

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: NIH/3T3 cells, LoVo cells, Primary antibody: (ATP2A1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes

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  The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using (ATP2A1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

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  The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using (ATP2A1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)

Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: ELISA: 2000-5000, WB: 200-1000, IHC: 50-200
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide of human ATP2A1
• Formulation: pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 110 kDa
• Gene Name: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
• Database Link:
  NP_775293
  Entrez Gene 11937 MouseEntrez Gene 487 Human
  UniProt ID O14983
• Background: This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms.
• Synonyms: ATP2A; SERCA1

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease, Calcium signaling pathway