CD18 (ITGB2) Rabbit Polyclonal Antibody
Rabbit Polyclonal Anti-ITGB2 Antibody
Product Datasheet for 'TA350097'
|Recommend Dilution||ELISA: 2000-5000, WB: 500-2000, IHC: 25-100|
|Immunogen||Fusion protein of human ITGB2|
|Formulation||pH7.4 PBS, 0.05% NaN3, 40% Glyceroln|
|Purification||Antigen affinity purification|
|Predicted Protein Size||85 kDa|
|Gene Name||integrin subunit beta 2|
|Background||The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.|
|Synonyms||CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7|
|Protein Families||Druggable Genome, Transmembrane|
|Protein Pathways||Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Natural killer cell mediated cytotoxicity, Regulation of actin cytoskeleton, Viral myocarditis|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.