PTCH1 Rabbit Polyclonal Antibody

CAT#: TA347455

Rabbit Polyclonal Anti-Patched Antibody

Product Images

Western blot analysis on mouse muscle cell lysate using Patched Antibody

Specifications

Product Data

• Applications: WB
• Recommended Dilution: WB: 1:500-1:3000
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: The immunogen for anti-Patched Antibody: A synthesized peptide derived from human Patched
• Formulation: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 160 kDa
• Gene Name: patched 1
• Database Link:
  NP_000255
  Entrez Gene 19206 MouseEntrez Gene 5727 Human
  UniProt ID Q13635
• Background: PTCH1 a multi-pass membrane protein member of the patched family that acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Interacts with SNX17. Expressed in tumor cells but not in normal skin.
• Synonyms: BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
• Note: Patched antibody detects endogenous levels of total Patched

Reference Data

• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer