PTCH1 Rabbit Polyclonal Antibody

CAT#: TA347455

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Rabbit Polyclonal Anti-Patched Antibody


Product Datasheet for 'TA347455'


USD 345.00


Availability*
4 Weeks

Size
    • 100 ug


Product images

Specifications

Product Data
Applications WB
Recommend Dilution WB: 1:500-1:3000
Reactivity Human, Mouse
Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen The immunogen for anti-Patched Antibody: A synthesized peptide derived from human Patched
Formulation Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20?. Stable for 12 months from date of receipt
Concentration 1 mg/ml
Purification Affinity-chromatography
Predicted Protein Size 160 kDa
Gene Name patched 1
Background PTCH1 a multi-pass membrane protein member of the patched family that acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. Interacts with SNX17. Expressed in tumor cells but not in normal skin.
Synonyms BCNS; HPE7; NBCCS; PTC; PTC1; PTCH; PTCH11
Note Patched antibody detects endogenous levels of total Patched
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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ANTIBODY VALIDATION 101
68 Mouse Clones