ATF3 Rabbit Polyclonal Antibody

CAT#: TA336705

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Rabbit Polyclonal ATF3 Antibody


 Product Datasheet for 'TA336705'

USD 450.00


Availability*
5 Days

Size
    • 100 ul


Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution WB: 1:200, ELISA: 1:100-1:2000, IHC: 5 ug/ml, IHC-P: 5 ug/ml
Reactivity Human, Mammalian, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide corresponding to a region of human ATF3 (within residues 100-150). [UniProt# P18847]
Formulation PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration 1.27 mg/ml
Purification Immunogen affinity purified
Predicted Protein Size 17 kDa
Gene Name activating transcription factor 3
Background ATF3 (activating transcription factor 3) belongs to ATF/CREB family of transcription factors and it binds Cre 5'-GTGACGT[AC][AG]-3' a sequence which is present in several cellular as well as viral promoters. ATF3 exerts its repressive effects on transcription from promoters with ATF sites by stabilizing the binding of inhibitory cofactors of target promoters. Expressed by various cell types with nuclear localization, ATF3 expression gets upregulated by a variety of extracellular stimuli such as cytokines, chemokines, growth factors, hormones, hypoxia, DNA damage, ER stress and starvation. Originally considered a stress-response gene, ATF3 now has emerged as a factor implicated in general adaptive responses such as environmental, emotional and nutritional alterations. Its disorders have been associated with inflammatory and immune diseases as well as cancer, and unlike other ATF/CREB family members, ATF3 is emerging as a factor involved in protection against malignant cells and invading pathogens.
Synonyms activating transcription factor 3; ATF3deltaZip2; ATF3deltaZip2c; ATF3deltaZip3; OTTHUMP00000034887; OTTHUMP00000034890
Note This ATF3 antibody is useful for Western Blot, ELISA and Immunohistochemistry paraffin embedded sections.
Reference Data
Protein Families Transcription Factors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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ANTIBODY VALIDATION 101
68 Mouse Clones