LIMPII (SCARB2) Rabbit Polyclonal Antibody

CAT#: TA336640

Rabbit Polyclonal LIMPII/SR-B2 Antibody


USD 457.00

5 Days*

Size
    • 100 ul

Product Images

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Specifications

Product Data
Applications FC, ICC/IF, IHC, WB
Recommended Dilution Flow Cytometry, Immunocytochemistry/ Immunofluorescence: 1:25-1:100, Western Blot: 1:1000, Immunohistochemistry-Paraffin: 1:25, Immunohistochemistry: 1:25
Reactivities Human, Mouse, Rat, Bovine, Hamster
Host Rabbit
Clonality Polyclonal
Immunogen A peptide containing residues from mouse SR-BII (between residues 400-478) plus an N-terminal cysteine was coupled to KLH. [UniProt# O35114]
Formulation Tris-citrate/phosphate, pH 7, 0.1% Sodium azide. Store at 4C. Do not freeze.
Concentration lot specific
Purification Whole antisera
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 82 kDa
Gene Name scavenger receptor class B member 2
Background Scavenger receptor class BI or SCARB1 gene belongs to CD36 receptor family and encodes for at least two mRNA splice variants which are SR-BI and SR-BII, among which SR-BII variant is the main isoform in terms of mRNA levels in certain tissues. For example, SR-BII mRNA is 48-fold higher than SR-BI in brain cells and protein levels reaching 10-15% of SR-BI in the liver. Similar differential SR-BII protein expression levels have also been detected in considerable amounts in other tissues, such as testes, retinal pigment epithelial cells, and spleen. SR-BII isoform differs from SR-BI only in its entirely different, yet highly conserved, cytoplasmic C-terminus which has been proposed to contains a signal responsible for marked alterations in cellular distribution as well as cellular trafficking of SR-BII compared with SR-BI. In contrast to SR-BI, SR-BII mediates the rapid uptake of significant amounts of HDL into endosomal recycling compartment by a pathway which is different from selective lipid uptake at the cell surface (mediated by SR-BI). Because SR-BII influence cellular cholesterol trafficking/homeostasis in a manner distinct from SR-BI, the relative expression as well as functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
Synonyms AMRF; CD36L2; EPM4; HLGP85; LGP85; LIMP-2; LIMPII; SR-BII
Note This SR-BII antibody is useful for Immunohistochemistry paraffin embedded sections, Immunocytochemistry/Immunofluorescence and Western blot. In Western blot a band is observed at ~82 kDa in tissues that express SR-BII such as liver, testes, and adrenal glands. Flow Cytometry was reported in scientific literature.
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Lysosome

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.