Gremlin 1 (GREM1) Rabbit Polyclonal Antibody
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Transient overexpression lysate of gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis) (GREM1)
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Other products for "Gremlin 1"
Specifications
Product Data | |
Applications | IHC |
Recommended Dilution | Immunohistochemistry: 1:20-1:1000, Immunohistochemistry-Frozen), Immunohistochemistry-Paraffin: 2.5-10 ug/ml |
Reactivities | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | A synthetic peptide containing amino acids QPGSRNRGRGQGRGTA (52-67) of human CKTSF1B1 (NM_013372). |
Formulation | PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
Concentration | lot specific |
Purification | Protein G purified |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Gene Name | gremlin 1, DAN family BMP antagonist |
Database Link | |
Background | In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis. |
Synonyms | C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2 |
Note | Immunohistochemistry cryosections reported in literature (See Namkoong et al, 2006 for antibody usage). |
Reference Data | |
Protein Families | ES Cell Differentiation/IPS, Secreted Protein |
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