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D4 (ARHGDIB) Mouse Monoclonal Antibody [Clone ID: 97A1015]

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SKU
TA336465
Mouse Monoclonal D4-GDI/RhoGDI2 (cleavage specific) Antibody (97A1015)
Size:
100 ug
Conjugation:
Unconjugated
  $610.00
5 Days*
Bulk/Customize

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View other "D4 or NM_001175" antibodies

Specifications
Specifications
Product Data
Clone Name 97A1015
Application FC, IHC, IP, WB
Recommended Dilution Flow Cytometry: 0.5-1 ug/10^6 cells, Immunohistochemistry: 1:10-1:500, Immunoprecipitation: 1-2 ug/ml, Western Blot: 2 ug/ml, Immunohistochemistry-Paraffin: 1:10-1:500, Flow (Intracellular): 0.5-1 ug/10^6 cells
Reactivity Human, Mouse
Antibody Host Mouse
Isotype IgG2b, kappa
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to the region of the Fas-induced cleavage site of human D4-GDI/RhoGDI2 was used as the immunogen.
Buffer PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Gene Name Rho GDP dissociation inhibitor beta
Database Link
Background D4-GDI (GDP dissociation inhibitor) is a negative regulator of the ras-related Rho family of GTPases. Since the Rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kD mature form of D4-GDI to give a 23 kD and 5 kD size fragment. The 23 kD fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-terminal kinase, a regulator of apoptosis, may be one of the mechanisms.
Synonyms D4; GDIA2; GDID4; Ly-GDI; LYGDI; RAP1GN1; RhoGDI2
Reference Data
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Neurotrophin signaling pathway
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.