TLR2 Mouse Monoclonal Antibody [Clone ID: TL2.1]

CAT#: TA336462

Mouse Monoclonal TLR2 Antibody (TL2.1)


TA336462 is a replacement of TA320480.

USD 457.00

5 Days*

Size
    • 100 ug

Product Images

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Specifications

Product Data
Clone Name TL2.1
Applications Block/Neutralize, Dot, ELISA, FC, ICC/IF, IP, WB
Recommended Dilution Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunoprecipitation: 2-5 ug, Western Blot: 1 - 2 ug/ml, Flow Cytometry: 1 ug/10^6 cells, Functional, Block/Neutralize, Flow (Cell Surface), Dot Blot, In vitro assay, ELISA
Reactivities Human, Canine
Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen This antibody was raised by immunizing mice with CHO cells transfected with human TLR2 cDNA (Flo et al, 2000). The hybridoma supernatants were selected by flow cytometry.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name toll like receptor 2
Background The Toll-like receptors (TLRs) in mammals comprise a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and an IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TLR2 is differentially expressed in human cells. TLR2 is expressed in tonsils, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes expressed the highest level of TLR2 followed by CD15+ granulocytes, and CD19+ B-cells, CD3+ T-cells, and CD56+ NK cells did not express TLR2. The expression of TLR2 in different cell types is regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes (4).
Synonyms CD282; TIL4
Note Immunocytochemistry/Immunofluorescence: please see Mempel et al. (2003) for details Immunohistochemistry (paraffin): please see Faure et al. (2001) for details Western Blot: please see Faure et al. (2001) for details
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Toll-like receptor signaling pathway

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.