NF-kB p65 (RELA) Mouse Monoclonal Antibody [Clone ID: 112A1021]

CAT#: TA336457

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Mouse Monoclonal RelA/NFkB p65 Antibody (112A1021)



USD 479.00


Availability*
In Stock

Size
    • 100 ug


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Specifications

Product Data
Clone Name 112A1021
Applications FC, IHC, WB
Recommended Dilution WB: 2-5 ug/ml, FC: 0.25-0.5 ug/10^6 cells, IHC: 5-15 ug/ml, IHC-P: 5 ug/ml
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1, kappa
Clonality Monoclonal
Immunogen This antibody was raised against a synthetic peptide corresponding to amino acids 526-539 of human NF-kB (p65) protein.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name RELA proto-oncogene, NF-kB subunit
Background NF-kB (nuclear factor kB) regulates the expression of a large number of genes that play critical roles in apoptosis, viral replication, tumorigenesis, various autoimmune diseases and inflammation. The active nuclear form of the NF-kB transcription factor complex is composed of two DNA binding subunits, NF-kB p65 and p50, both of which share extensive N-terminal sequence homology with the v-rel oncogene product. N-terminal regions of p50 and p65 are critical for DNA binding and help determine the DNA-binding specificities of p50 and p65.
Synonyms NFKB3; p65
Note Western Blot and Flow cytometry/analysis (Intracellular) as reported in the literature (Wittmann et al, 2005). IHC (paraffin) as reported in the literature (Chang et al, 2005)
Reference Data
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Cytosolic DNA-sensing pathway, Epithelial cell signaling in Helicobacter pylori infection, MAPK signaling pathway, Neurotrophin signaling pathway, NOD-like receptor signaling pathway, Pancreatic cancer, Pathways in cancer, Prostate cancer, RIG-I-like receptor signaling pathway, Small cell lung cancer, T cell receptor signaling pathway, Toll-like receptor signaling pathway
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