Prion protein PrP (PRNP) Rabbit Polyclonal Antibody

CAT#: TA336430

Rabbit Polyclonal Prion protein Antibody

Product Images

Western Blot: PrPC Antibody TA336430 - Analysis of BSE in (A) recombinant fusion protein containing amino acids 162-170 and (B) fusion partner without these amino acids, using this antibody at 5 ug/ml.

Specifications

Product Data

• Applications: WB
• Recommended Dilution: Western Blot: 0.5-2 ug/ml
• Reactivities: Bovine, Sheep, Avian
• Host: Rabbit
• Clonality: Polyclonal
• Immunogen: Amino acids 162-170 of BSE protein were used as the immunogen.
• Formulation: PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Protein G purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: prion protein
• Database Link:
  NP_898902
  Entrez Gene 5621 Human
  UniProt ID F7VJQ1
• Background: BSE, also known as prion protein, is a membrane glycosylphosphatidylinositol-anchored glycoprotein belonging to the prion family of proteins and is responsible for several transmissible neurodegenerative spongiform encephalopathies. Though the exact function of BSE is not clear, reports suggest that it has a tendency to aggregate forming polymers known as rods and might act as a signaling neurotransmitter. BSE acts as a potent anti-apoptotic protein against BAX-mediated cell-death. Expression is higher in the brain of humans and animals infected with several degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy (TME). Aberration in this protein is also associated with fatal familial insomnia and Huntington disease-like 1.
• Synonyms: AltPrP; ASCR; CD230; CJD; GSS; KURU; p27-30; PRIP; PrP; PrP27-30; PrP33-35C; PrPc

Reference Data

• Protein Families: ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transmembrane
• Protein Pathways: Prion diseases